Abstract
One of the factors of male infertility is idiopathic oligospermia in which the causative factor is not known. A direct case control, two-centers, prospective, randomized controlled two-arm parallel group trial was carried out to investigate the safety and efficacy of trialed medicine in Shifa-ul-Mulk Memorial Hospital for Eastern Medicine at Madinat-ul-Hikmah, Hamdard University Karach-74600, Pakistan. An assessment was conducted on the coded herbal formula Spermox (Test drug) to treat idiopathic condition of oligospermia; the test drug spermox was compared with Fertilox (Control drug). The idiopathic pathogenic states of spontaneous origin were detected on 62 clinically diagnosed patients. The conclusive findings were significant as improvements were seen in clinical assessment and semen analyses parameters. The value of sperm count per milliliter in spermox was found more than 29 million in 26 patients (p 0-032). It revealed that Spermox is more effective in upgrading the semen quality and quantity when compared with Fertilox for the treatment of idiopathic oligospermia. This is clearly evident that Spermox (Test drug) possesses a more viable value for the treatment of idiopathic oligospermia in comparison to Fertilox (Control drug). Key words: Oligospermia, herbal medicine, male infertility, prospective, multicentre, randomized, clinical trial.
Highlights
Oligospermia is the deficiency of spermatozoa in the semen and is the basic cause of male infertility
Aspragus recemosu, M. pruriens, A. adscendens, W. somnifera, and T. terrestris, the first three plants directly act on sperm motility and increment of sperm counts and related factors, whereas Withnia sominfera is an immunity enhancer and Tribulus terresteris is spermogenic
The finding from this study demonstrated the following salient clinical assessment; there was statistically significant difference when comparing the effectiveness of herbal treatment Spermox to Fertilox for the treatment of idiopathic oligospermia as described in the thesis
Summary
Oligospermia is the deficiency of spermatozoa in the semen and is the basic cause of male infertility. The quality and quantity of semen having reduced sperm concentration display a marked abnormality in sperm morphology and motility and vitality The associated risk may be involved in producing condition, including age, infection of Chlamydia trachomatis, Y chromosome deletions due to aberration mitochondrial changes, chemical effects of environmental hazards and hormonal changes (Cavallini, 2006). It is understood that in most cases of oligospermia and idiopathic form there is no direct medical or surgical involvement found to be curative. Despite the fact that it is comprehended that by and large of idiopathic oligospermia, there is no immediate therapeutic or surgical contribution discovered to be remedial at yet. The diverse therapeutic methodologies have been attempted. The treatment of idiopathic oligospermia and male infertility by using
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