English

Abstract

Background and Objectives: The characteristic rhythmic changes in the rate of secretion of ovarian hormones produce corresponding changes not only in the reproductive system but in other organ systems as well. This study was intended to evaluate the variation in the pulmonary functions during different phases of menstrual cycle in healthy females. Methods: This was a prospective, observational study performed on 50 healthy, regularly menstruating subjects. Their lung functions were measured during various phases of menstrual cycle and the various parameters were compared. Results: FVC and FEV1 were significantly higher during the luteal phase as compared to menstrual and follicular phases. PEF was increased in the luteal phase as compared to menstrual and follicular phase but was not statistically significant. This study indicates that changes occur during different phases of menstrual cycle and that endogenous female hormones have measurable influence on lung mechanics. Conclusion: The pulmonary functions were better during the luteal phase of menstrual cycle thus suggesting a possible beneficial role of progesterone in the management of respiratory diseases.