Abstract

BACKGROUND: HBV Virus is one of the major health problems in India. Hepato cellular carcinoma due to HBV infection is 5th most frequent cancer in world wide. About 30% population has serological evidence of current or past infection with HBV. In the natural history of HBV infection, the most important event is HBeAg, Seroconversion is characterized by loss of HBeAg and development of antibody against HBeAg. AIMS: The aim of the study was to determine sero prevalence of hepatitis B infection among different age, sex groups and to understand the risk factors that define the development of HBsAg. DESIGN The study design was based on clinical evaluation and serological testing. METHODS: The study was conducted in the Department of Microbiology of a tertiary care hospital, G.B. Panth Hospital. Agartala, West Tripura during the period over 5 years, 2001 – 2005.In this retrospective study, total 21, 121 numbers of patients serum were examined by ELISA method to detect the Hepatitis B surface antigen in different categories of patient as a marker of infection. out of 21, 121 patients, 1044 number of cases were seropositive showing the prevalence rate 4.94% in compared with hepatitis B virus infection in India is 4%. Details clinical history, age, sex, risk factors were recorded carefully.

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