Abstract
In this study, the crude methanolic extracts of whole palnt of Typha elephantina Roxb. were directed for screening of thrombolytic activity, membrane stabilizing activity, and total phenolic content. Human erythrocytes were taken for the analysis of both thrombolytic and membrane stabilizing activities and here streptokinase (SK) and acetyl salicylic acid (ASA) were used as standard for both tests, respectively. The methanolic extract of whole plant demonstrated high level of thrombolytic activity at the concentration of 4 mg/ml (33.33% of clot lysis) among various concentrations such as 2, 4, 6, 8, 7 and 10 mg/ml. On the other hand, the methanolic extract at different concentrations (1, 3, 5, 7 and 9 mg/ml), dose dependently inhibited the % of haemolysis of red blood cell (RBC) in case of heat induced condition and in case of hyponotic solution induced haemolysis, the methanolic extract just protected the RBC membrane. The total phenolic content (TPC) determination was investigated as a part of antioxidant assay. For the TPC determination, Folin-Ciocalteu method was used and the total phenolic content (126.33±4.33) of methanolic extract of T. elephantina was expressed by milligram of gallic acid equivalent to per gram of extract. Key words: Typha elephantina Roxb., thrombolytic activity, membrane stabilizing activity, total phenolic content.
Highlights
Medicinal plants are defined as the plants which are beneficent for the recuperation of various diseases (Shahriar et al, 2014)
The present study was an attempt to determine the thrombolytic, membrane stabilizing properties and total phenolic content of methanolic extract of T. elephantina Roxb. and the results have been circumscribed in Tables 1, 2 and 3, respectively
As a part of searching drugs having capability to facilitate blood clot lysis from natural sources, the extractives of T. elephantina was examined for thrombolytic potential and the results are presented in Table 1. 100 μl SK, which was used as positive control (30,000 I.U.) exerted 40.13 ± 0.39% clot lysis activity
Summary
Medicinal plants are defined as the plants which are beneficent for the recuperation of various diseases (Shahriar et al, 2014).
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