Abstract
This assessment aims to identify the increasing number of morbidity of drug susceptible tuberculosis (TB) and its treatment outcomes, government cost of medicines as well as the economic impact on society. A retrospective observational study had been conducted in a government hospital using a patient’s record from 2013 to 2017, treated under the Direct Observed Therapy Short Course (DOTS) program in Karachi, Pakistan. Altogether, 3872 drug-susceptible TB patients were included in the study. All data had been analyzed using SPSS version 16 software. It had been found from the data that each year number of new smear-positive TB patients remained same, that is, 85% in 2013, 90% in 2014, 89.5% in 2015, 91% in 2016 and 92.3% in 2017 while slight decrease in relapse cases, that is, 15, 10, 10.4, 9 and 7.6% in 2013 to 2017, respectively. The single factor analysis of variance (ANOVA) shows that there is no significant difference between the gender of TB patient throughout the duration with the p-value=0.3769. During the years of study, cost of medicine increased due to rapid rise of inflation in the region which inturn caused the significant financial constraint on patients and their families. moral and financial support are important to render an individual productive again in the society. Key words: Drug-susceptible tuberculosis (DS-TB), anti-tubercular therapy, cost of medicine.  
Highlights
Tuberculosis (TB) is leading infectious disease in developing countries which commonly affect a momentous number of populations
In Pakistan, TB has been one of the most widespread diseases and over 1.5 million individuals had been suffering from TB as it is considered the 2nd primary reason for death (World Health Organization, 2012; Yadav et al, 2012)
It is widespread in Pakistan because of the lack of financial resourses by government as well as non-government organizations, lack of disease awareness as TB is highly contagious and implementation of new preventive, diagnostic and therapeutic measures in public health care setups (Simou and Koutsogeorgou, 2014)
Summary
Tuberculosis (TB) is leading infectious disease in developing countries which commonly affect a momentous number of populations. In 2016, there had been an approximated 10.4 million people diagnosed with TB in which adults were 90%, male were 65%, 10% of people suffering were with HIV (74% in Africa) while 56% people had been found in 5 countries, that is, India, Indonesia, China, the Philippines, and Pakistan while in 2016, WHO. WHO efforts associated to control and to lessen the pulmonary TB affirmed TB as a global emergency in the year 1993. This concluded that TB has been continuous as well as the main burden of mortality all over the world
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