English

Abstract

BACKGROUND Dengue is an acute viral haemorrhagic fever with large number of fatalities worldwide. According to WHO, 50 - 100 million infections occur annually, out of which 5 lakhs are dengue haemorrhagic fever. India is no way better like any other tropical country. Southern part of Odisha shows high prevalence of dengue cases which are referred to MKCG Medical College, Berhampur. Dengue is a vector borne disease, which is of much epidemiological importance throughout India. No clinical study has been undertaken in recent past on this disease as regard to clinical parameter, course and outcome. Hence, it was decided to carry out a study to assess the epidemiological profile of dengue patients, the prevalence and pattern of liver and kidney dysfunction and outcome of hospitalized patients in MKCG Medical College and Hospital. METHODS This cross-sectional study was carried out on laboratory confirmed dengue patients admitted to hospital in Department of Medicine, MKCG Medical College & Hospital, Berhampur from January 2018 to December 2018. RESULTS More number of patients (58 %) were male and from rural area (72 %). Alanine aminotransferase (ALT) and aspartate aminotransaminase (AST) were elevated in 68 % of cases to more than 3 times of normal. Mortality is 4 % among the admitted patient. More death observed with high international normalized ratio (INR) value. CONCLUSIONS Mortality is high in patients of dengue with deranged liver function and kidney function. Early screening of dengue patients by clinical and laboratory parameter will help clinicians to predict mortality for dengue cases. Dengue cases with liver and kidney dysfunction need aggressive monitoring and appropriate management to prevent complications and death. KEYWORDS Severe Dengue, Early Parameters, AST / ALT, Outcome, Mortality