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Abstract
Depression is among the leading causes of disability worldwide and its global burden seems to further increase in the future. In the present study, in silico approach was used to assess the use of constituents of Zingiber officinale as potential agents that could act as antidepressant agents. Docking studies of Gingerol and Shogoal were carried out using Argus lab 4.0.1. Analysis of the results of the docking software suggested that Gingerol and Shogoal can act as potent antidepressants. For the binding analysis, 5HT1A receptor protein was taken for the study as it is considered being a potential target for treatment of depression. The standard drug, imipramine was subjected to docking analysis for comparative study. Further analysis in the wet lab may provide more information regarding antidepressant activity of Z. officinale. Key words: Zingiber officinale, Argus lab 4.0.1, docking, depression, 5HT1A receptor.
Highlights
Depression is among the leading causes of disability worldwide and its global burden seems to further increase in the future
The serotonin 5-HT1A receptor (5-HT1AR) is a G-protein coupled receptor widely expressed in the central nervous system (CNS), where it is involved in the modulation of mood, emotion and depression, and of different behavioral responses, including thermoregulation, sleep, feeding, aggression, and anxiety
Of all the serotonin receptor subtypes, 5-HT1AR is the dominant receptor responsible for depression and it is involved in the mechanism of action of several antidepressant drugs (Nievergelt et al, 2010)
Summary
Depression is among the leading causes of disability worldwide and its global burden seems to further increase in the future. A number of drugs are available for the treatment of depression, but clinical evaluation of these drugs has shown incidence of relapses, side effects, and drug interactions. This has been the rationale for the development of new antidepressants, which includes herbal drugs (Rajput et al, 2011). The serotonin 5-HT1A receptor (5-HT1AR) is a G-protein coupled receptor widely expressed in the central nervous system (CNS), where it is involved in the modulation of mood, emotion and depression, and of different behavioral responses, including thermoregulation, sleep, feeding, aggression, and anxiety. A number of natural antidepressant compounds have been reported in the medicinal plants and tested for their efficacy in treating depression. The present study aims to investigate the antidepressant activities of the compounds from Zingiber officinale against the 5-HT1A receptor protein by using Argus lab 4.0.1
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