Abstract
The present investigation was to examine the in vivo antioxidant activity and lipid peroxidation activities of different extracts of aerial parts of Chomelia asiatica (Linn). High fat diet rats demonstrated fundamentally decreased the levels of tissues enzymatic antioxidant and non-enzymatic antioxidant (Glutathione). The level of thiobarbuturic acid reactive substance (TBARS) is reduced in high-fat diet (HFD) rats when compared and control group. Administration of ethyl acetate extract of Chomelia asiatica in high fat diet rats were indicated altogether (p<0.001) increased the levels of antioxidant enzymes, for example, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and level of non enzymatic antioxidant glutathione (GSH) when contrasted and HFD rats (Group II). The ethyl acetate extract of C. asiatica in high fat diet rats were discovered lowered the concentration of TBARS when contrasted and HFD rats. In comparison of all the three extracts treated group with standard group, the ethyl acetate extract of C. asiatica showed significant (p<0.001) result than that of other groups. Taking into account the outcomes, we concluded that the ethyl acetate extract of C. asiatica is a significant source of antioxidant, which may be useful in keeping the advancement of different oxidative stresses. Key words: Chomelia asiatica, in vivo antioxidant, lipid peroxidation, rats.
Highlights
Oxidation is essential in many living organisms for the production of energy to fuel biological processes
The thiobarbuturic acid reactive substance (TBARS) and conjugated dienes levels were increment in liver, heart and aorta in II group rats are a clear reasonable sign of excessive formation of free radical and initiation of lipid peroxidation
The significantly (p
Summary
Oxidation is essential in many living organisms for the production of energy to fuel biological processes. The uncontrolled production of oxygen derived free radicals is involved in the onset of many diseases such as atherosclerosis, rheumatoid arthritis, and cancer as well as in degenerative processes associated with aging (Halliwell et al 1984). Antioxidants are often used in oils and fatty foods to retard their autoxidation. Ethnomedical literature contains a large number of plants that can be used against diseases, in which reactive oxygen species and free radical play important role. Recent reports indicate that there is an inverse relationship between the dietary intake of antioxidant-rich foods and the incidence of human diseases (Halliwell, 1997). No data are available in the literature on the antioxidant activity of aerial parts of C. asiatica. We undertook the present investigation to examine the in vivo antioxidant and lipid peroxidation activities of different extract of aerial parts of C. asiatica (Linn) in rat fed with high fat diet
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