Abstract
p16 is a tumor suppressor protein and also a cyclin-dependent kinase inhibitor and HPV-L1 (L1) is a capsidic protein that is expressed in the early, productive phase of cervical carcinogenesis. To provide evidence for the evaluation of endometrial intraepithelial neoplasia (CIN), the expressions of p16 and HPVL1 in different cervical diseases were determined and their relationship was explored. Immunohistochemistry was performed to detect the expressions of p16 and HPVL1 in women positive for HPV among whom 38, 32, 28, 33 and 10 had CIN I, CIN II, CIN III, cervical squamous cell carcinoma (SCC) and cervical adenocarcinoma, respectively. Fourteen healthy subjects were recruited as controls. Results showed the positive rate of p16 in cervicitis, CIN I, CIN II, CIN III,cervical SCC and cervical adenocarcinoma patients was 0, 26.3, 81.2, 96.4, 100 and 90%, respectively, and that of HPVL1 was 100, 65.8, 13.8, 0, 0 and 0%, respectively. p16(-)/HPVL1(+) was frequently found in patients with cervicitis or cervical lesions of low grade and p16(+)/HPVL1(-) was often noted in women with CIN III or cervical cancer. The cervical lesions of patients with p16(-)/HPVL1(-) or p16(+)/HPVL1(+) might have no progression or undergo degeneration. Detection of p16 and HPVL1 expressions plays an important role in the prediction of early cervical cancer and its progression. Key words: Cervical tumor, cervical intraepithelial neoplasia, human papilloma virus, HPVL1 protein, p16.
Highlights
Cervical cancer is one of the most common malignancies in women
Results showed the positive rate of p16 in cervicitis, cervical intraepithelial neoplasial I (CIN I), CIN II, CIN III, cervical squamous cell carcinoma (SCC) and cervical adenocarcinoma patients was 0, 26.3, 81.2, 96.4, 100 and 90%, respectively, and that of HPVL1 was 100, 65.8, 13.8, 0, 0 and 0%, respectively. p16(-)/HPVL1(+) was frequently found in patients with cervicitis or cervical lesions of low grade and p16(+)/HPVL1(-) was often noted in women with CIN III or cervical cancer
No significant difference was noted among CIN III, cervical SCC and cervical adenocarcinoma patients (Table 1 and Figure 1)
Summary
Cervical cancer is one of the most common malignancies in women. It is very well known that human papilloma virus HPV undeniably plays a role in the development of most cervical cancers. Only a minority of women positive for HPV develop cervical cancer. The possibility of predicting the behavior of low-grade cervical lesions could be of high value in clinical practice, potentially allowing an individualized management of cervical lesions depending on their progression risk. Many studies have proposed that p16 is a useful biomarker especially for HR (high risk)-HPV type-related cervical neoplasia and for predicting squamous intraepithelial lesion (SIL) progression (Yildiz et al, 2007). A few other studies have recently concluded that there exists a significant association between cervical lesion grade and p16 staining distribution and intensity (Lambert et al, 2006)
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