Abstract
The ethanolic extracts of leaves of Psidium guajava (PG), Pandanous odorus (PO),Rhinacanthus nasutus (RN) contained polyphenolic compounds in the order of PG > RN > PO. All the extracts exhibited 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2’-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging activities. PG showed a marked antioxidant effect whereas PO and RN were comparable. Interestingly, they were able to bind with ferric (Fe3+) and ferrous (Fe2+) ion and completed within 5 min of incubation times. In accordance with previous results, PG extract could effectively protect erythrocytes from iron induced hemolysis with the activity higher than PO and RN. Based on all results, tested leaf extracts of three Thai medicinal plants might be used for alleviating or preventing harmfulness in many oxidative stress disorders. Key words: Psidium guajava, Pandanous odorus, Rhinacanthus nasutus, antioxidant, iron binding capacity, anti-hemolysis activity.
Highlights
Oxygen consumption of cells generates a series of reactive oxygen species (ROS) (Moskovitz et al, 2002)
Erythrocytes are vulnerable to oxidative stress due to their high content of polyunsaturated lipids and transition metals, especially iron, which is known to catalyze free radicals generation via Fenton reaction (Chiu et al, 1982)
This study aims to investigate the antioxidant properties of three Thai traditional plant extracts including Psidium guajava L., Pandanous odorus and Rhinacanthus nasutus
Summary
Oxygen consumption of cells generates a series of reactive oxygen species (ROS) (Moskovitz et al, 2002). Erythrocytes are vulnerable to oxidative stress due to their high content of polyunsaturated lipids and transition metals, especially iron, which is known to catalyze free radicals generation via Fenton reaction (Chiu et al, 1982). In some disorders such as thalassemia and chronic renal disease, ROS production is higher than normal (Nematbakhsh et al, 2013; Shazia et al, 2012). There is powerful defense system for prevention of oxidation, erythrocytes of such patients demonstrate an increased ROS and decreased content of antioxidants than their normal counterparts (Amer et al, 2004; Das et al, 2004; Fibach et al, 2010; Ounjaijean et al, 2008). This study aims to investigate the antioxidant properties of three Thai traditional plant extracts including Psidium guajava L., Pandanous odorus and Rhinacanthus nasutus
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