Abstract
Three groups (10 in each) (6 to 8 weeks old) of experimental mice were orally infected each with 500 (group A) 1000 (group B) and 2000 (group C) infective larvae of Ancylostoma caninum . Group (D) was kept as uninfected control for comparison. Two mice from each of the experimental groups were sacrificed on day 1, 4, 9, 16 and 30 after infection. Two mice from control group were also sacrificed on the same designated days. Spleen was separated and the content of DNA and RNA was estimated following standard methods. DNA and RNA levels in spleen of experimental groups (A, B and C) are lower and higher than control group during 1 to 30 days of infection respectively. The synthesis of DNA and RNA was influenced by three varied doses of infection; the occurrence of abnormal physiological changes in spleen indicates the influence of infection in the lymphoid organ.
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