English

Abstract

OBJECTIVES: The present study was designed to evaluate the association of lipid profile in pre- eclampsia and if there is any change in lipid profiles in pre-eclampsic mother as compared to no pregnant woman and normotensive pregnant mother. METHODS: This case-control study was carried out in the department of Obstetrics and gynaecology of Burdwan medical college, Burdwan from 1st June 2012 to 31st May 2013.Total 180 patient were evaluated of which 60 were non-pregnant normotensive,60 were pregnant normotensive and 60 were pre-eclamptic mother. Age group was in between 19-35 years. In case of pregnancy gestational age was in between 32 to 36 weeks. Patients with pre-existing hypertension were excluded. Serum lipid profile (total cholesterol, triglycerides, HDL-cholesterol VLDL and LDL cholesterol) of one hundred and eighty women with Pre-eclampsia (n=60), normotensive non pregnant women (n=60) and normotensive pregnant woman (n=60) were monitored .Comparison is drawn and analysed by using chi-square test (SPSS 18 software). RESULTS: In preeclampsia there is significant decrease of High density lipoprotein(HDL) and significantly increase of Low density lipoprotein(LDL),Very low density lipoprotein (VLDL) and Triglycerides concentration seen compared to non pregnant normotensive and pregnant normotensive subjects. CONCLUSION: Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia and Eclampsia. Increased triglycerides, total cholesterol, LDL, VLDL levels along with decreased HDL-cholesterol levels and high blood pressure are associated with development of preeclampsia and eclampsia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of this disorder.