English

Kumar Verma Rohit,Mittal Piyush,Barua Ankur,Kumar Suresh

doi:10.5897/sre11.1035

English

Kumar Verma Rohit, Mittal Piyush + Show 2 more

Open Access

https://doi.org/10.5897/sre11.1035

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Abstract

Pain control in chronic and acute disease conditions such as cancer pain or post-operative pain is often adequate with the help of appropriate pharmacological agent. A comprehensive review of numerous studies conducted to evaluate the efficacy of hydromorphone (OROS) for the management of acute and chronic pain was performed. Data from 17 controlled trials were reviewed, taking into consideration the usefulness of hydromorphone for the management of chronic and acute pain. Heterogeneity of the studies and the small number of patients involved made the conclusion difficult. Overall the studies found that osmotic-controlled released oral delivery system (OROS) hydromorphone that is effective in the management of chronic pain. But comparative studies with other opioid analgesics find little difference in efficacy and side effect profile. OROS hydromorphone is effective in the management of chronic pain, but it’s usefulness in acute pain is less conclusive.   Key words: Hydromorphone, osmotic-controlled released oral delivery system (OROS), chronic pain, acute pain.

Highlights

Hydromorphone is a semi-synthetic micro receptor agonist opioid and hydrogenated ketone of morphine (Vallner et al, 1981)
There is good evidence shown that the analgesic potential of hydromorphone is equivalent to other opiod in acute pain management
The osmotic-controlled released oral delivery system (OROS) hydromorphone is a once daily dosage form from which tend to administer the drug at a constant rate and a consistent analgesic effect over 24 h period is given

Summary

Introduction

Hydromorphone is a semi-synthetic micro receptor agonist opioid and hydrogenated ketone of morphine (Vallner et al, 1981). There is good evidence shown that the analgesic potential of hydromorphone is equivalent to other opiod in acute pain management. In a randomized and double-blind clinical trial, 198 adults are presented to the emergency department with acute severe pain and were randomized to receive either intravenous hydromorphone or intravenous morphine.

Results

Conclusion