Abstract
The use of electrospun fibers in diabetic wound healing assays represents an extremely important topic for investigation. Electrospun fibers have been applied in the immobilization of drugs, allowing sustained and controlled release of active materials. This review aimed to summarize the state-of-art in the application of electrospun fibers on diabetes, hyperglycemic and diabetic ulcers treatment. Regarding the diabetes control and treatment, electrospinning technique contributes to application of wound healing (in vitro and in vivo experiments). The glycemic control is favored due to controlled release which has been sustained and improved. The data suggest that the development of encapsulated drugs in electrospun fibers has a promising application in the treatment of diabetes and related complications. Key words: Electrospun fibers, nanofibers, electrospinning technique, anti-diabetic drugs, hypoglycemic drugs, wound healing.
Highlights
This review aimed to summarize the state-of-art in the application of electrospun fibers on diabetes, hyperglycemic and diabetic ulcers treatment
Diabetes mellitus is a metabolic disease characterized by insufficiency in insulin secretion, insulin action, or both (ADA, 2014) that results in hyperglycemia
This study shows that the insulin cannot be released from the composite nanofiber patch due to the crosslinking between the drug molecule and polymeric chains unless polymeric nanofibers are degraded
Summary
Diabetes mellitus is a metabolic disease characterized by insufficiency in insulin secretion, insulin action, or both (ADA, 2014) that results in hyperglycemia. The International Diabetes Federation (IDF) estimates that in 2040, 10% of adult population will be diabetics. Considering the South and Central America, this number increases to 65% (IDF, 2015). Numerous pathogenic processes are consequence of diabetes, due to the several pathologies involving heart, blood vessels, eyes, kidneys and nerves (ADA, 2014; IDF, 2015; Chen et al, 2015). Diabetic wound healing has been considered one of major complications of diabetes mellitus (Siersma et al, 2014) which results in peripheral neuropathy and/or large vessel disease complicated by trauma (Singh et al, 2005; Boulton, 2008). Recent studies have demonstrated that new therapies can be used in the control of blood
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