Abstract
The aim of this study was to study the anti-inflammatory effect of a compound containing volatile oils of Flos magnoliae, Centipeda minima and Mentha haplocalyx. The anti-inflammatory effect of the compound was investigated using xylene-, egg white- and cotton pellet-induced inflammation method. The medium- and high-doses of the compound (0.04 and 0.08 ml/kg) significantly inhibited the xylene-induced ear swelling in mice; low-, medium- and high-doses of the compound (0.02, 0.04, and 0.08 ml/kg) all had significant inhibitory effects on degree of paw swelling 30 min after the induction of inflammation; high-dose of the compound (0.08 ml/kg) significantly lowered the weight of cotton pellet granuloma in rats. The compound has a preferable therapeutic effect on both the acute and chronic inflammations, which can be developed as an anti-inflammatory traditional Chinese medicine. Key words: Anti-inflammation, Flos magnoliae, Centipeda minima, Mentha haplocalyx, volatile oil.
Highlights
The formula of the aromatic rhinitis spray consists of three traditional Chinese herbs, namely Flos magnoliae, Centipeda minima and Mentha haplocalyx
The results revealed that the compound medium- and high-dose groups significantly inhibited xylene-induced ear swelling in mice (P
C. minima is pungent in flavor, and warm in nature, it acts on the lung channel, clears the nasal passage, facilitates nine orifices, and expels wind phlegm
Summary
The formula of the aromatic rhinitis spray consists of three traditional Chinese herbs, namely Flos magnoliae, Centipeda minima and Mentha haplocalyx. Through the analysis and identification, it was found out from the study of Qin et al (2001) that the main composition of volatile oil from F. magnoliae were aromatic alcohol compounds and unsaturated ester compounds. Modern pharmacological studies have shown that F. magnoliae has an astringent effect, which can improve local blood circulation and promote the absorption of secretions, thereby diminishing inflammation, clearing nasal passage, and relieving or eliminating symptoms (Tao, 1996); it has an anti-allergic effect, which can effectively fight against the nasal itching, sneezing, runny nose, and other symptoms caused by allergic rhinitis (Wen-bin et al, 2002). Br. et Aschers., which belongs to the Compositae plant family, it has the effects of dispersing wind-cold, clearing nasal passage, and relieving cough. The anti-inflammatory effect of a compound containing these three herbs was studied, providing the basis for the development of the compound
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