Abstract
Ovarian cancer is the most common female malignancy and the main cause of death from gynecological malignancies. Resveratrol (3,4,5 tri-hydroxystilbene) is a phytoalexin and a polyphenolic compound present in human dietary material such as peanuts, mulberries, grapes and red wine. We demonstrated that resveratrol depressed the proliferation of HO8910PM cells in a dose-dependent and time-dependent manner in vitro (P < 0.001). Resveratrol not only decreased ovarian tumor volume and weight but also influence the tumor forming time in vivo (P < 0.001). The cell cycle S phase was arrested in response to resveratrol treatment. Caspases activity were also detected by western-blotting in HO8910PM cells treated with resveratrol. Caspase-3 or/and caspase-9 were highly activated in resveratrol-treated HO8910PM cells or xerngraft model (P < 0.001). Resveratrol significantly inhibits growth and induces apoptosis in HO8910PM cells both in vitro and in vivo, suggesting that resveratrol is a potential treatment or supplementary measure of ovarian carcinoma. Key words: Resveratrol, ovarian cancer, apoptosis, cytochrome C, caspase.
Highlights
Ovarian cancer is the most common female malignancy and ranks first in mortality (Siegel et al, 2014), with a 5year survival rate as low as 30% (Liao et al, 2014)
We demonstrated that resveratrol depressed the proliferation of HO8910PM cells in a dose-dependent and time-dependent manner in vitro (P < 0.001)
Resveratrol has been considered as a potential anticancer agent that displays pleiotropic effects and has a multitude of biochemical and molecular actions, including inhibition of free radical formation and activities of cyclooxygenase (COX), inducible nitric oxide synthase, cytochrome P-450 and protein kinase C
Summary
Ovarian cancer is the most common female malignancy and ranks first in mortality (Siegel et al, 2014), with a 5year survival rate as low as 30% (Liao et al, 2014). Due to the difficulties in early detection, the majority of patients are diagnosed with advanced epithelial ovarian cancer with widespread metastatic disease. The patients with advanced ovarian cancer is hard to treat successfully even with the current multi-modal therapies available. Anticancer therapy has identified as methods able to efficiently inhibit cell growth or commit cells to apoptosis. Previous studies have indicated that some natural supplements exhibit potent anti-tumor properties and modulate apoptosis, differentiation and cell cycle. Most of these chemotherapeutic agents may cause serious side effects on necessitated high doses, whereas natural
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