Abstract
The peripheral nervous system has the ability to regenerate after injury. Peripheral nerve injuries are caused by penetrating injury, crush, traction and ischemia compression. However, the availability of various nerve coaptation and other techniques for the attainment of functional nerve regeneration is still inadequate. The objective of this study was to compare the effectiveness of bone marrow stromal cells (BMSCs) implantation and epineural nerve suture on peripheral nerve regeneration in a rabbit model. Ten male New Zealand white rabbits were divided into two groups. In the primary epineural repair group (control group), the left sciatic nerve was skeletonized from the sciatic notch to the point of bifurcation, with the nerve been transected at the mid-shaft of the femoral bone and repaired with six epineural sutures. In the treated group, the epineural repaired nerve was implanted with BMSCs in the proximal and distal segments of the transected sciatic nerve. Assessment of the nerve regeneration was based on functional (motor and sensory), histological and morphometric criteria, including the number of myelinated nerve fibers, nerve fiber diameter, axon diameter, myelin sheath thickness, g ratio and relative gastrocnemius muscle weight. The results of the examination showed that the treated group had the best regeneration and functional recovery. Keyword: Bone marrow stromal cells (BMSCs), histopathology, morphometric, peripheral nerve, regeneration.
Highlights
Peripheral nervous system injuries include penetrating injuries, crush, traction and ischemia compression (Robinson, 2004)
The onset and ability to walk on day 14 post operations (PO) in the bone marrow stromal cells (BMSCs) group was significantly different (p ≤ 0.05) as compared to the epineurial nerve suture (ENS) group
On day 56 PO, the type of gait became normal in the BMSCs group with a significant difference (p ≤ 0.05) as compared to the ENS
Summary
Peripheral nervous system injuries include penetrating injuries, crush, traction and ischemia compression (Robinson, 2004). Microsurgical suture repair remains the current gold standard in clinical practice (Lundborg, 2000), but obvious deficiencies remain with this technique, given that surgical repair of peripheral nerves does not result in complete functional recovery. Recent approaches have been directed towards biological factors to promote an environment conducive for growth and overcome limitations in regeneration and functional. Al-Timmemi et al 8977 nerve suture on peripheral nerve regeneration in a rabbit model
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