Abstract
To present the current situation of prophylactic use of antibiotics for clean operative procedures in the department of surgery of our hospital, a total of 2000 cases with clean operative procedures were randomly selected from January 2011 to June 2011 and reviewed. Results showed all patients received prophylactic use of antibiotics (100%), which was performed at 0.5 to 2 h before surgery in 1204 cases (60.2%), at >2 h before surgery in 452 cases (22.6%), before and during surgery in 19 cases (0.95%) and after surgery in 325 cases (16.25%). Cephalosporin antibiotics were the most frequently used in 1883 cases (94.15%). Combination application of antibiotics was found in 254 cases (12.7%). The indications for prophylactic use of antibiotics in patients undergoing clean operative procedures are extensive, high-level antibiotics are used, the time of antibiotic delivery is improper and the post-operative appli-cation of antibiotics is long. Therefore, it is imperative to control the improper prophylactic application of antibiotics and develop strict principles for prophylactic application of antibiotics. Key words: Rational drug use, prophylactic therapy, antibiotics, clean operative procedure.
Highlights
In the surgical field, the preventive effect of antibiotics on the surgical site infection (SSI) is indubitable
To present the current situation of prophylactic use of antibiotics for clean operative procedures in the department of surgery of our hospital, a total of 2000 cases with clean operative procedures were randomly selected from January 2011 to June 2011 and reviewed
Results showed all patients received prophylactic use of antibiotics (100%), which was performed at 0.5 to 2 h before surgery in 1204 cases (60.2%), at >2 h before surgery in 452 cases (22.6%), before and during surgery in 19 cases (0.95%) and after surgery in 325 cases (16.25%)
Summary
The preventive effect of antibiotics on the surgical site infection (SSI) is indubitable. Proper prophylactic application of antibiotics can help to reduce the SSI but decline the incidence of drug resistance. SSI refers to the infection of surgical incision or deep organ/space following surgery, including incision infection, brain, abscess peritonitis, etc. SSI accounts for 15% of hospital acquired infection and 35 to 40% of infections in the department of surgery. According to the Cruse statistics, the incidence of wound infection was about 1% in clean operative procedure (Surgery Branch of Chinese Academy of Medical Sciences and Editorial Board of Chinese Journal of Surgery, 2006). 2 to 5% of patients undergoing clean extra-abdominal operations and up to According to the Cruse statistics, the incidence of wound infection was about 1% in clean operative procedure (Surgery Branch of Chinese Academy of Medical Sciences and Editorial Board of Chinese Journal of Surgery, 2006). 2 to 5% of patients undergoing clean extra-abdominal operations and up to
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