Abstract
Cardiovascular disease and oxidative stress are involved in aging. Aging causes many alterations in myochardial functions and metabolism. The aim of this study was to investigate the effect of aging on heart functions, total antioxidant capacity and membrane lipid composition and the effects of oral administration of ginger and lipoic acid for 30 days. The levels of serum lactate dehydrogenase, creatine kinase and heart antioxidant capacity exhibited marked alterations in normal senile female rats. The treatment of ginger and lipoic acid for 30 days improved these alterations. Furthermore, the relationship between membrane lipid composition and aging was detected. There were significant increases in lauric and myristic acids and significant decrease in arachidic acid in senile rats. On the other hand, the unsaturated fatty acids (olic, linoleic, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were significantly decreased. Ginger treatment showed significant decreases in saturated fatty acids. In lipoic acid treated group, there was a significant improvement in the level of unsaturated fatty acids (EPA and DHA) as compared with normal senile female rats. In conclusion, ginger and lipoic acid may have ameliorative effect of heart functions, total antioxidant capacity and membrane free fatty acids in old female rats. Key words: Ginger, lipoic acid, senile, heart, antioxidant, free fatty acids.
Highlights
Aging is a major factor for the development of oxidative damage and heart disease (Gao et al, 2013) and associated with fibrosis and inflammation that leads to cellular senescence (Li et al, 2014). Shih et al (2011)stated that myocardial infarction and chronic heart failure increased with age
The present study aimed to evaluate the age-related changes on heart tissue in normal female senile rats and the effect of oral administration of two antioxidants ginger and lipoic acid administered for 30 days on the heart functions, antioxidant activity and membrane free fatty acids
Significant increases was observed in serum creatine kinase-MB level in senile groups and this increase diminished after the treatment with ginger or lipoic acid as compared with adult control and ginger treated groups
Summary
Aging is a major factor for the development of oxidative damage and heart disease (Gao et al, 2013) and associated with fibrosis and inflammation that leads to cellular senescence (Li et al, 2014). Stated that myocardial infarction and chronic heart failure increased with age. Heart is provided with antioxidant systems to scavenge excess reactive oxygen species (ROS), repair oxidative stress and maintain sulfhydryl homeostasis (Meyer et al, 2009). Demonstrated that myochardial antioxidant status decreased and lipid peroxidation increased with age. Antioxidant reduced the reactive oxygen species which causes carcinogenesis, DNA damage, heart disease and other health problems revealed to advancing age (Yeh et al, 2014). Ginger acts as a hypolipidimic factor in which it stimulates the conversion
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
