English

Akber Samoo Hadia,Hussain Khaskheli Aftab,Akbar Shah Syed,Sattar Qureshi Abdul,Muhammad Babar Atta,Hameed Sheikh Ather,Ahmad Khokhar Jawaid,Aqeel Bhutto Muhammad,Khushk Imrana,Maheshwari Jagarwanti

doi:10.5897/ajb2018.16445

Abstract

This study investigates the effect of barley (Hordeum vulgare), black plum (Syzygium cumini) and Chinese tree leaves (Pistacia chinesis) aqueous extracts on serum glucose, cholesterol, urea, uric acid level and body weight of normal and alloxan-induced diabetic male rabbits. Rabbits were kept in fasting condition for 12 h, then diabetes was induced using alloxan monohydrate (150 mg/Kg) . From the 7th day of diabetes induction, blood serum was collected for glucose analysis. Rabbits having fasting glucose level ≥ 250 mg/dL were considered as diabetic. Rabbits were treated with 1% barley, black plum and Chinese tree aqueous extract to check their effects on the serum glucose, serum cholesterol, serum urea, uric acid and body weight of the animals. Samples were collected after every 72 h for biochemical analysis. It was noted that 1% barley, black plum and Chinese tree aqueous extract reduced 43.92, 39.05 and 32.47% glucose level. Results suggest that oral administration of aqueous extract of barley, black plum and Chinese tree reduced glucose, cholesterol, urea, and uric acid level. Therefore, these medicinal plants should be supplemented as herbal drugs in the treatment of various complex diseases and specially to control diabetes. Key words: Chinese tree leaves, antidiabetic agents, barley, black plum, rabbits, diabetes mellitus.

Highlights

Diabetes mellitus is one of the chronic diseases that occur either due to decrease in insulin secretion or lack of insulin peripheral activity (Mutalik et al, 2003); it approximately causes half of all deaths occurring at the age of 70
This study investigates the effect of barley (Hordeum vulgare), black plum (Syzygium cumini) and Chinese tree leaves (Pistacia chinesis) aqueous extracts on serum glucose, cholesterol, urea, uric acid level and body weight of normal and alloxan-induced diabetic male rabbits
These medicinal plants should be supplemented as herbal drugs in the treatment of various complex diseases and specially to control diabetes

Summary

Introduction

Diabetes mellitus is one of the chronic diseases that occur either due to decrease in insulin secretion or lack of insulin peripheral activity (Mutalik et al, 2003); it approximately causes half of all deaths occurring at the age of 70. Diabetes mellitus has two types, Type 1 occurs due to βcell destruction, and is mostly insulin dependent diabetes (Alberti and Zimmet, 1998); type-2 is triggered by mutation in β-cell gene, and is the most common forms of adulthood onset diabetes caused by change in glucokinase and HNF-1 alpha genes. Type diabetes remains undiagnosed because hyperglycaemia does not show any symptoms; such patients may develop micro.

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