Abstract
Securinega virosa (Euphorbiaceae) together with condiments from natural sources serve as antisickling remedies in Nigeria. This study was aimed at establishing the pharmacognostic profile as well as the antisickling activity of the leaves of S. virosa Roxb. ex Willd (Euphorbiaceae). Evaluation of the fresh, powdered and anatomical sections of the leaves were carried out to determine the macromorphological, micromorphological and chemomicroscopic characters. Chemical tests were employed in phytochemical investigations. Evaluation of the antisickling activity involved the inhibition of sodium metabisulphite-induced sickling of the HbSS red blood cells obtained from confirmed sickle cell patients who were not in crises. Concentrations of the crude extract and its fractions were tested with normal saline and p-hydroxybenzoic acid serving as controls. Microscopical studies showed anomocytic stomata arrangement and glandular trichomes. Phytochemical evaluation revealed the presence of tannins, flavonoids, alkaloids, saponins and cardiac glycosides. Percentage sickling inhibitions of the aqueous methanol extract of S. virosa as well as all the fractions, except the petroleum ether fractions were significant all through the period of assay p < 0. 05 compared to normal saline. These results are suggestive of a potential role for S. virosa in the management of sickle cell disorders and a candidate for further investigations. Key words: Securinega virosa, euphorbiaceae, pharmacognostic standardization, sickle cell disorders. 
Highlights
Fu ull Length h Researc ch PaperTh his study wa as aimed at establishing e g the pharma acognostic p profile as we ell as the he fresh, antisickling g activity of the t leaves of o S. virosa Roxb
Pharma acogno ostic evaluat e tion an nd antisicklin ng activity off the e leaves of Se ecurinega viirosa R
Th his study wa as aimed at establishing e g the pharma acognostic p profile as we ell as the he fresh, antisickling g activity of the t leaves of o S. virosa Roxb
Summary
Th his study wa as aimed at establishing e g the pharma acognostic p profile as we ell as the he fresh, antisickling g activity of the t leaves of o S. virosa Roxb. Che emical tests were employ yed in phytoc chemical investigatio ons. Evaluatiion of the an ntisickling ac ctivity involv ved the inhib bition of sod dium metabisulphiteinduced sic ckling of the HbSS red blood cells ob btained from m confirmed s sickle cell pa atients who were not ns of the crrude extract and its frac in crises. Th hese results are sugges stive of a potential ro ole for S. viirosa in the management of sickle cell disorders and a c candidate fo or further investigatio ons. Desspite all the progress in synthetic s che emistry and biob technology, plan nts are still an indispens sable source of medicinal prepa arations, both h for preven ntion and cu ure.
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