Abstract
This study aimed to investigate the effect of zinc supplementation on testicular tissue as a feed-back mechanism of the pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on cigarette smoker subjects. Total of twenty subjects participated in this study as per the national bioethics committee guidelines. Venous blood samples were collected for determination of serum level of LH and FSH before and after zinc supplementation. LH and FSH determination were done using enzyme-linked immunosorbent assay (ELISA). A t-test was used to compare the means of two groups, P value was considered significant if ≤ 0.05. Results showed that LH serum levels were elevated in smokers as compared to the control group (p 0.05). Similar observation was found in FSH levels (p>0.05). After one month of zinc supplementation, LH levels decreased in smokers group (after: 4.14 ± 2.38 mlU/ml, before: 7.43 ± 4.32 mlU/ml; p>0.05). FSH levels also decreased after zinc supplementation in smokers group (after: 1.50 ± 1.12 mlU/ml, before: 3.88 ± 1.57 mlU/ml; p>0.05). The improving effect of zinc supplementation on LH and FSH pituitary and testicular steroid secretions for smoker subjects is obviously observed. These findings can be implemented to contribute to the outcome of zinc treatment associated with smoking. Key words: Zinc, biometals, smoking, gonadotropins, luteinizing hormone (LH), follicle-stimulating hormone (FSH), trace elements.
Highlights
Cigarette smoke contains a large number of oxidative compounds
This study aimed to investigate the effect of zinc supplementation on testicular tissue as a feed-back mechanism of the pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on cigarette smoker subjects
The LH serum level was found to have a very high significant increase in smokers group before zinc supplementation compared to nonsmokers group as illustrated in Table 1 (p>0.05)
Summary
Cigarette smoke contains a large number of oxidative compounds. Both zinc and antioxidants delay the progression of oxidative degeneration, possibly by preventing cellular damage. There are numerous functions in which zinc plays an important role such as prostate gland function and reproductive organ growth, immune function, protein synthesis , wound healing, DNA synthesis and cell division (Heiserman, 1992; Solomons, 1998; Prasad, 1995; Heyneman, 1996). It supports normal growth and development of fetus during pregnancy and after birth in childhood and adolescence (Fabris and Mocchegiani, 1995; Maret and Sandstead, 2006). Zinc plays key role in different sensory functions like proper sense of taste
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