Abstract
Lovastatin is an anti-lipidemic drug produced by various filamentous fungi as a secondary metabolite. In our study, Pleurotus ostreatus was used in the production of lovastatin by solid state fermentation process. P. ostreatus was grown on different substrate (wheat bran, rice bran, rice straw, sugarcane bagasse), from which the maximum yield was obtained when wheat bran was used as a substrate in solid substrate fermentation. Further, wheat bran was used as a substrate and was grown on different temperatures (25, 28, 32 and 35°C), in which a maximum yield was obtained at 28°C. To determine its anti-lipidemic property and other medicinal properties like anti cancer, Alzheimer's disease a docking study was done using Auto dock Vina, in which various proteins responsible for the disease are targeted and studied. The docking studies prove that lovastatin can effectively help in the treatment of various diseases by effectively binding to various proteins which are responsible for cancer, apoptosis and Alzheimer's. Key words: Lovastatin, fermentation, wheat bran, hydroxymethylglutaryl CoA reductases, Alzheimer disease.
Highlights
Lovastatin is a first known drug in statin family which was discovered in 1970s (Endo, 1976)
Various temperatures (25, 28, 32 and 35°C) was maintained in P. ostreatus culture and their effect on lovastatin was determined on day seven
The maximum yield of lovastatin was obtained from wheat bran, which may be due to easy absorption of nutrients from them and due to maintenance of moisture content in the substrate
Summary
Lovastatin is a first known drug in statin family which was discovered in 1970s (Endo, 1976). It was initially produced from Aspergillus terrus (Endo, 1976). Various other organisms like Pleurotus ostreatus (Samiee et al, 2003), a marine actinomycetes (Srinu et al, 2010), Aspergillus parasiticus, Accremonium chrysogenum (Endo, 1992), Monascus pirpureus (Danuri, 2008) has the ability to produce lovastatin. Various other statin drugs were synthesized from lovastatin by semi-synthetic process. A huge study is being done for the production of lovastatin through solid state fermentation process as a low cost substrates like wheat bran, rice straw can be used, and the water and power consumption are very less when compared
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