Abstract
Isolation of multidrug resistant Escherichia coli from diseased livestock is becoming rampart from samples submitted for disease diagnostic purposes in some Tertiary Veterinary Teaching Hospitals in Nigeria. In order to evaluate the possible roles of commensal E. coli from apparently healthy animals in the epidemiology of drug resistant pathogens, antibiotic resistance status of 240 E. coli isolated from 300 rectal swab from apparently healthy cattle from a major cattle market in Ibadan, Oyo State, South West Nigeria (a location very close to two of the Veterinary Teaching Hospitals), were grown aerobically at breakpoint concentration for ciprofloxacin, cefepime, chloramphenicol, tetracycline, ampicillin, kanamycin, streptomycin and nalidixic acid (all obtained from SIGMA-ALDRICH) according to standard method by Clinical Laboratory Standards Institute. A very high level of resistance was observed in all the antibiotics studied, with the highest resistance of 97% for kanamycin and 96.7, 95.8, 73.8, 72.5, 61.7, 56.3 and 51.3% for ampicillin, chloramphenicol, tetracycline, cefepime, nalidixic acid, streptomycin and ciprofloxacin, respectively. The high resistance observed in the commensal E. coli could be attributed to antibiotic selective pressure due to often abuse/misuse of the drugs on the cattle. The findings in this work are of public health importance because these multidrug resistant E. coli can transmit resistance to other pathogenic bacteria of livestock and human pathogen. Key words: Antimicrobial, resistance, healthy cattle, isolated.
Highlights
Antibiotic resistance among microorganisms is a major problem, both in human and livestock industry
In order to evaluate the possible roles of commensal E. coli from apparently healthy animals in the epidemiology of drug resistant pathogens, antibiotic resistance status of 240 E. coli isolated from 300 rectal swab from apparently healthy cattle from a major cattle market in Ibadan, Oyo State, South West Nigeria, were grown aerobically at breakpoint concentration for ciprofloxacin, cefepime, chloramphenicol, tetracycline, ampicillin, kanamycin, streptomycin and nalidixic acid according to standard method by Clinical Laboratory Standards Institute
In Nigeria livestock industry, the problem of occurrence of multidrug resistant E. coli is becoming very rampart, because they are often encountered in routine diagnoses of disease conditions from livestock brought for confirmatory diagnosis in microbiology diagnostic units of some Tertiary Veterinary Teaching Hospitals in Nigeria
Summary
Antibiotic resistance among microorganisms is a major problem, both in human and livestock industry. In Nigeria livestock industry, the problem of occurrence of multidrug resistant E. coli is becoming very rampart, because they are often encountered in routine diagnoses of disease conditions from livestock brought for confirmatory diagnosis in microbiology diagnostic units of some Tertiary Veterinary Teaching Hospitals in Nigeria (unpublished data). Earlier in Nigeria, Ogunleye et al (2008), reported nineteen different multidrug resistant patterns to commonly available antibiotic in E. coli isolated from some diseased poultry samples from eleven poultry farms in Abeokuta, Ogun State, Nigeria. Each of the E. coli isolates studied were resistant to between 5 and 12 commonly used antibiotics such as nitrofurantoin, cefuroxime, norfloxacin, cotrimoxazole, nalidixic acid, chloramphenicol, ampicilin, ofloxacin, penincilin G, amoxylin, cloxacilin and ciprofloxacin(Ogunleye et al, 2008)
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