Abstract
The present study was designed to investigate the hypoglycemic effects of the daily oral dose of 0.50 to 0.75 g/kg of yeast hydrolysate (YH) containing high Cyclo-His-Pro (51.0 mg CHP/g YH) on normal and streptozotocin (STZ)-induced diabetic rats for 14 days. In STZ-induced diabetic rats, after administrations of the YH for 14 days, the body weight gain was significantly increased in dose dependent manner, and the plasma glucose levels were decreased approximately (60%) as compared to the STZ induced diabetic control group. Glucose level showed significant differences between the diabetic control (DC) and the YH administered groups in oral glucose tolerance test (OGTT) (P<0.05). Results of the OGTT showed a significant decrease in the area under curve (AUC) value of YH supplemented groups as compared to the DC group. The present data suggests that the CHP-enriched YH has potential anti-diabetic effect, which can help in the cure and management of diabetes. Key words: Yeast hydrolysate, Cyclo-His-Pro (CHP), diabetes, streptozotocin.
Highlights
Diabetes mellitus (DM) is one of the major endocrine disorder and global public health problems, affecting nearly 10% of the world’s population
In STZ-induced diabetic rats, after administrations of the yeast hydrolysate (YH) for 14 days, the body weight gain was significantly increased in dose dependent manner, and the plasma glucose levels were decreased approximately (60%) as compared to the STZ induced diabetic control group
Mean weight gains in the YH administered groups were significantly higher (P
Summary
Diabetes mellitus (DM) is one of the major endocrine disorder and global public health problems, affecting nearly 10% of the world’s population. In the last few decades, there has been exponential growth in the field of alternatives by natural supplements, owing to their natural origin and lesser side effects (Yeh et al, 2003), since natural sources are usually considered to be less toxic with fewer side effects than synthetic sources (Pari and Umamaheswari, 2000). They have the potential to impart therapeutic effect in complicated disorders such as diabetes and its complications (Tiwari and Rao, 2002)
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