Abstract
Many pathological conditions are associated with pain, fever and inflammation. Synthetic drugs available for the treatment of these ailments accompany many unwanted side effect; most prominent of which is the gastric ulcer. Present study was thus aimed at evaluating the analgesic, anti-pyretic and anti-inflammatory potential of aqueous methanolic extract of leaves of plant Jatropha gossypifolia. Anti-inflammatory activity was evaluated using carrageenan induced paw edema. Acetic acid induced writhing test and hot plate method was used to assess the analgesic activity. Anti-pyretic activity was ascertained using brewer’s yeast induced pyrexia. The aqueous methanolic extract of the plant J. gassypifolia have demonstrated significant analgesic, anti-pyretic and anti-inflammatory activity at 200 mg/kg dose. The data was statistically analyzed by one way ANOVA followed by post hoc Dunnett’s test for multiple comparisons. It has thus concluded that aqueous methanolic extract of leaves of plant J. gassypifolia possess analgesic, anti-inflammatory and anti-pyretic properties. These results strongly support the ethno-pharmacological use of this plant as anti-pyretic, analgesic and anti-inflammatory agent. Key words: Jatropha gossypifolia, anti-inflammatory, analgesic, anti-pyretic.
Highlights
The study showed that the plant extracts of J. gassypifolia demonstrated significant peripheral as well as central analgesic activity, at a dose level of 200 mg/kg of body weight (Khan, 1992)
The central analgesic activity was evaluated and the plant extract of J. gassypifolia showed dose dependent increase in latency time and the analgesic effect was found to be 58% at 200 mg/kg dose as compared to 93% for reference drug tramadol 20 mg/kg (Table 2)
Results of the present study revealed that leaves of the plant J. gassypifolia possess significant analgesic, antipyretic as well as anti-inflammatory activity
Summary
Medicine health care system (Shinwari, 2010) The use of such medicinal plants as remedy against various ailments is known by the name of hikmat. 40,000 of such registered hakims are practicing as health care professional using plant extracts for curing various diseases (Saeed et al, 2011). Jatropha gossypifolia plant belongs to the family “Euphorbiaceae” is locally known as “Lal bherandha” This plant family possesses about 170 different types of species (Kamal et al, 2011). The decoction of the leaves is useful for stomach ache, venereal diseases and as a blood purifier (Vickers, 2001) This plant was been used in various skin related ailments and some blood related disorders. In the present study the aqueous methanolic extract of leaves of the plant J. gassypifolia had been used for its potential analgesic, anti-inflammatory and anti-pyretic activity in animal models
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