English

Rabiul Islam Md,Ahmed Moudud,Parvin Shahnaj,Fatema Tuz Zahra Syeda,Haque Tazmel,Abu Talha Siddique Md,Hasan Kamrul,M Ibrahim Sumon S

doi:10.5897/ajpp2019.5017

Abstract

The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the analysis, it was shown that for the H. contortus at 100% concentration, the paralysis occurred within the shortest time (P=24.5 min) and death came at the lowest possible time (D=56 min). The time of death and paralysis increased at 50% (D=64 min and P=28 min) and 25% concentration (D=74 min and P=34 min), respectively compared to the Piperazine citrate (P= 24 min and D= 54) at concentration of 10 mg/ml. Here, distilled water is as a control solution. The results of this study revealed that the ethanolic extracts of the leaves of the C. papaya expressed a demonstrated paralysis significantly, and also responsible for the death of P. cervi and H. contortus especially at the higher concentration (100%) compared to the standard reference of Piperazine citrate. Therefore, from the results it is declared that the ethanolic extracts of the leaves of C. papaya showed a great anthelmintic activity against P. cervi and H. contortus worms. Hence, the present research work signifies that the leaf of C. papaya has a major anthelmintic activity and also can be used as a potent drug for its low cost and availability. Key words: Paramphistomum cervi and Haemonchus contortus, anthelmintic, Carica papaya leaves, Albendazole. &nbsp

Highlights

The word “anthelmintic” is from the Greek word, “anti” which means “against” and “helminis” means “worm”which means “to kill or wipe out worms or parasites”
The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms
The results of this study revealed that the ethanolic extracts of the leaves of the C. papaya expressed a demonstrated paralysis significantly, and responsible for the death of P. cervi and H. contortus especially at the higher concentration (100%) compared to the standard reference of Piperazine citrate

Summary

Introduction

The word “anthelmintic” is from the Greek word, “anti” which means “against” and “helminis” means “worm”which means “to kill or wipe out worms or parasites”. Helminthiasis or helminth infection is a parasitic disease of humans and other animals in which a part of the body is infected with parasitic worms (Paramphistomum cervi and Haemonchus contortus). They often live in the gastrointestinal (GIT) of their hosts, but may stay in other organs. GIT is the abode of many helminths, but some live in tissues, or their larvae migrate into tissues They harm the host by depriving them of food, causing blood loss, injury to organs, intestinal or lymphatic obstruction and by secreting toxins (Tripathi, 2003)

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Results