Abstract
The poor bioavailability and therapeutic response exhibited by the conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling systems that are instilled as drops into the eye and undergo a sol-togel transition in the cul-de-sac. The present study was designed to prepare and investigate the sustained release in situ ocular gels of Tobramycin sulphate using gelrite as gel forming polymer, which is used in the treatment of various bacterial infections. The formulations were evaluated with various parameters like clarity, pH, gelling capacity, rheological study, in vitro studies, sterility and isotonicity. All the formulations were transparent, having consistency and drug content was found to be in acceptable range. Among all the formulations, F3 was selected as the best formulation. The best selected F3 formulation was found to be stable at short term stability studies as per ICH guidelines. The overall results of this study supports that the Gelrite based vehicle could be used for controlled drug release that exhibits a greater potential for conjunctivitis. It also contributes to a great extent to patient compliance as the dosage is regulated as one drop of the solution to be instilled into the eye once a day.
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