English

Abstract

BACKGROUND Osteoarthritis is a common, age-related, chronic and slowly progressive joint disorder which ultimately leads to joint failure. To achieve sustained release drug delivery and ease of administration, the present study was carried out to formulate a glucosamine solid lipid microparticle-based hydrogel. METHODS 20 batches of glucosamine solid lipid microparticle were prepared by melt dispersion technique. They were then evaluated with regard to various parameters such as physical appearance, pH analysis, spreadability, viscosity, drug content, in vitro drug release and accelerated stability studies. Then the glucosamine solid lipid microparticle-based hydrogel was compared with the glucosamine loaded hydrogel. RESULTS Of these batches, batches 18, 19 and 20 of increasing homogenizing speed of 1000, 1500 and 2000 rpm were found be efficient but the batch 18 showed better encapsulation efficiency. Batch 18 showed particle size of 86 ± 5 µm, encapsulation efficiency of 81.74 ± 4.5 and the zeta potential value of - 29 ± 1. So, batch 18 was found to be the optimised formulation which was further taken for incorporating the Carbopol. The efficient encapsulated glucosamine solid lipid microparticle-based hydrogel was formulated. There were no significant changes in physicochemical properties on stability studies. CONCLUSIONS Glucosamine solid lipid microparticle-based hydrogel had good particle size, high encapsulation efficiency and high zeta potential value and showed high percentage drug release which was better than the glucosamine loaded hydrogel. KEY WORDS Glucosamine Solid Lipid Microparticle Based Hydrogel, Osteoarthritis, Encapsulation Efficiency, Zeta Potential, Melt Dispersion Technique