English

Abstract

AIM AND OBJECTIVE: This randomized prospective study was done to evaluate the effects of single premedication dose of I.V dexmedetomidine in attenuating pressor response to laryngoscopy and endotracheal intubation. METHODOLOGY: In this study, 60 patients in the age group 20-40yrs, belonging to ASA grade I and II scheduled for elective surgical procedures under general anaesthesia were included. The patients were randomly divided into 2 groups of 30 each. Group I patients received 100ml NS 15min before induction and Group II patients received Dexmedetomidine 1microgm/kg in 100ml NS 15mins before induction. HR, SBP, DBP, MAP were monitored at T0, T1, T2, T3, T4, T5, T6 respectively. Patients were maintained with O2, N2O, Isoflurane and vecuronium at titrated doses. ECG, NIBP, HR were monitored throughout the procedure. All patients were monitored for 24 hours post operatively. RESULTS: In Group II patients had attenuation of sympathetic response with decrease in HR, SBP, DBP and MAP where as in Group I there was increase in HR, SBP, DBP and MAP throughout the study period. Maximum changes in HR, SBP, DBP and MAP were observed at 1 min after intubation in both the Groups. In Group II there was a constant decrease in HR, SBP, DBP and MAP from the time of pre induction until 10 th min of intubation which when compared to that of Group I was statistically highly significant(p=0.000). There were no significant changes in ECG and SPO2 in both the Groups. Recovery was satisfactory without any side effects. CONCLUSION: Dexmedetomidine in the dose of 1μg/kg as IV infusion, given 15 minutes before induction can be used safely to attenuate the pressor response to laryngoscopy and intubation without any side effects. HR-Heart rate, SBP- Systolic blood pressure, DBP- Diastolic blood pressure, MAP- Mean arterial pressure, IV- Intravenous, T0- Basal reading when the patient is shifted to OR, T1- At 5mins after infusion of dexmedetomidine/saline, T2- At Induction (2mins after Thiopentone sodium+ vecuronium), T3- At 1 min after intubation, T4- At 3mins after intubation, T5- At 5mins after intubation, T6- At 10mins after intubation.