Abstract
This study was performed on culture and sensitivity of 6,951 urine samples, received in the Department of Microbiology, Christian Medical College & Hospital, Ludhiana from out patients and in patients having urinary tract infection (UTI ).A total of 2,276 samples were found out to be culture positive, out of which 1,727 samples yielded gram negative organisms. Various isolates included 1,237 Escherichia coli (E. coli), 262 Klebsiella pneumoniae,47 Acinetobacter lwoffi, 39 Proteus mirabilis,39 Enterobacter aerogenes and 03 Pseudomonas aeruginosa. Extended spectrum beta lactamase (ESBL) production was studied in multidrug resistant E. coli. And Klebsiella pneumoniae, out of which 28.29% E.coli and 30.53% Klebsiella pneumoniae yielded positive results. Our results suggest that the physician should be aware of high prevalence of ESBL producing E.coli and Klebsiella pneumonia which are the two common uropathogens, and should plan their therapy regime accordingly. However, Acinetobacter species were mainly associated with nosocomial UTI whereas Enterobacter species were isolated mostly from out patients. Various uropathogens causing community acquired as well as nosocomial UTI showed poor response to cephalexin whereas resistant strains from both types of UTI exhibited good susceptibility to piperacillin/tazobactum combination.
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