Abstract
Hugonia mystax (H. mystax) has been used in the siddha and ayurvedha for various ailments. In this study ethanolic crude extract (EEHM) of the leaves were studied for various analgesic methods. The ethanolic extract of H. mystax was spiked into the male swiss albino mice (weighing 20 to 25 g) and male wister rats weighing (150 to 200 g) and analyzed the analgesic activity by hot plate and acetic acid induced method. The phytochemical analysis of ethanolic extract of H. mystax showed the presence of carbohydrates, flavonoids, steroids, saponins, terpenoids and absence of alkaloids, proteins and amino acids. For acute toxicity test, mice were injected different doses of each extract by intraperitoneal route and the LD50 values were determined. The analgesic effect was evaluated in mice by the hot plate method and acetic-acid writhing test. The extracts have produced significant analgesic effects by the acetic acid writhing test and by the hot plate method (p <0.01) and a dose-dependent inhibition was observed. The overall results indicate the significant analgesic activity and also its justification for further traditional uses H. mystax leaves. Key words: Hugonia mystax, analgesic activity, toxicity.
Highlights
The genus Hugonia L. of family Linaceae comprise about40 species in the world; of which Hugonia mystax L. was reported from India and Srilanka (Santapau and Henry, 1983; Pullaiah and Chennaiah, 1997)
With addition to the fact that the compound containing analgesic activity nature was phytochemically identified in the ethanol extracts of leaf of H. mystax (Rajeswari et al, 2012) by gas chromatography-mass spectrometry (GC-MS) analysis and the result showed the H
The objective of the work was to prove the analgesic activity of H. mystax leaves through the techniques of hot plate and acetic acid induced method
Summary
40 species in the world; of which Hugonia mystax L. was reported from India and Srilanka (Santapau and Henry, 1983; Pullaiah and Chennaiah, 1997). Mystax were used as anthelmintic, astringent and used for dysentery, snake bite, fever, inflammation and rheumatism Biological activities such as analgesic, anti inflammatory and ulcerogenic were reported (Balasubramaniam et al, 1997; Guha et al, 2001). With addition to the fact that the compound containing analgesic activity nature was phytochemically identified in the ethanol extracts of leaf of H. mystax (Rajeswari et al., 2012) by GC-MS analysis and the result showed the H. mystax leaves containing the isoprenoid compound. We can make attempt by this analgesic character, later on the leaves extract showed the good result in the trail works We take this as the consideration and on the medicinal value and utility. The objective of the work was to prove the analgesic activity of H. mystax leaves through the techniques of hot plate and acetic acid induced method
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