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Abstract
The aim of this study was to observe the effect of early application of the Chinese Medicine Tongxinluo on cardiomyopathy in diabetic rats. 36 rats were randomly divided into normal control group, diabetic group and Tongxinluo (TXL) group. Streptozotocin was used for preparation of diabetic model of Sprague Dawley (SD) rats. Tongxinluo powder (1.43 g of crude drug/g dry powder) was dissolved in water and used for gavage at a dosage of 0.3 g kg-1 day-1. Blood glucose was detected 8 weeks later; left ventricular systolic pressure and left ventricular end diastolic pressure, maximum rise and fall rate of left ventricular pressure (± dp/dt max) were determined; myocardial pathological changes were observed under light microscopy and electron microscopy after Hematoxylin and eosin (HE) staining. ± dp/dt max in the diabetic rat group decreased, but ± dp/dt max of the Tongxinluo group increased, and the difference was significant (P < 0.05). Under light microscope, the myocardium myofibril of the diabetic group was deranged, and myofilament composition was reduced. Electron microscopy showed that cardiac endothelial cells were markedly swollen, and the basilar membrane of capillary vessel showed irregular obvious thickening. The lesions of the Tongxinluo group were mild. Tongxinluo can significantly improve cardiac function of diabetic rats and reduce diabetic cardiomyopathy. Key words: Tongxinluo, diabetic rats, diabetic cardiomyopathy.
Highlights
Diabetic cardiomyopathy (DCM) refers to a disease state in which a wide range of structural abnormalities is caused by primary cardiac myocyte injury in patients with diabetes, leading to left ventricular hypertrophy, diastolic and systolic dysfunction (Hayat et al, 2004), and is one of the major complications of diabetes, and is one of the main reasons leading to the death of patients with diabetes (Laakso, 1999).Since Rubler et al (1972) first proposed the diabetic cardiomyopathy, results of clinical, epidemiology, pathology and experimental studies all showed the presence of specific cardiomyopathy, instead of blood supply disorder secondary to coronary
Diabetic cardiomyopathy (DCM) is a specific condition which is primarily manifested by left ventricular remodeling and diastolic and/or systolic dysfunction (Shankar et al, 2007)
These pathological changes can be fundamentally ascribed to hyperglycemia-caused glucose and lipid disorders
Summary
Diabetic cardiomyopathy (DCM) refers to a disease state in which a wide range of structural abnormalities is caused by primary cardiac myocyte injury in patients with diabetes, leading to left ventricular hypertrophy, diastolic and (or) systolic dysfunction (Hayat et al, 2004), and is one of the major complications of diabetes, and is one of the main reasons leading to the death of patients with diabetes (Laakso, 1999).Since Rubler et al (1972) first proposed the diabetic cardiomyopathy, results of clinical, epidemiology, pathology and experimental studies all showed the presence of specific cardiomyopathy, instead of blood supply disorder secondary to coronary. Diabetic cardiomyopathy (DCM) refers to a disease state in which a wide range of structural abnormalities is caused by primary cardiac myocyte injury in patients with diabetes, leading to left ventricular hypertrophy, diastolic and (or) systolic dysfunction (Hayat et al, 2004), and is one of the major complications of diabetes, and is one of the main reasons leading to the death of patients with diabetes (Laakso, 1999). Diabetic cardiomyopathy may be asymptomatic, as the disease progresses, patients may have angina, arrhythmia and progressive cardiac dysfunction, due to the complexity of its causes but it has its own pathophysiological change, so there are certain difficulties in clinical research and treatment. Chinese medicine has some advantages in prevention of diabetes and its complications, but there are still many problems in the current study, the focus of most research is still limited to lower blood glucose; studies on diabetic cardiomyopathy is lagging behind and is still limited to the description of the phenomenon, and the study on mechanism is far from in-depth research
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