Abstract
The aim of this study was to determine whether tuberculosis (TB) treatment normalizes the lipid profile strongly affected by pulmonary TB. Serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were determined in 83 patients with pulmonary TB before and after treatment, and compared to results obtained from 100 control subjects without TB. Before treatment, levels of TC (p<0.005), HDL-C (p<0.005) and LDL-C (p<0.005) were significantly lower in pulmonary TB patients than normal subjects. Unlike TC and LDL-C, HDL-C decrease was correlated (r = 0.96, p<0.05) with smear positivity extent (SPE). At the end of TB treatment, which lasted six months, TC (p<0.01) and HDL-C (p<0.005) levels were significantly increased than before treatment while LDL-C stayed relatively unchanged. The treatment significantly reduced the atherogenic indices TC/HDL-C (p<0.001), LDL-C/HDL-C (p<0.001) and log (TG/HDL-C) (p<0.001) levels. Our results show that tuberculosis treatment increases TC levels and normalizes HDL while reducing atherogenic indices to below levels of controls. Key words: Pulmonary tuberculosis, lipid profile, treatment, atherogenic index.
Highlights
Cholesterol has received much attention in recent years mainly because of its involvement in cardiovascular disease (Smith et al, 1992)
Serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were determined in 83 patients with pulmonary TB before and after treatment, and compared to results obtained from 100 control subjects without TB
It is reported that hypocholesterolemia promotes the development of TB whereas hypercholesterolemia confers some protection against infection with Mycobacterium tuberculosis (MTB) (Wilson et al, 2003; Perez-Guzman et al, 2005)
Summary
Cholesterol has received much attention in recent years mainly because of its involvement in cardiovascular disease (Smith et al, 1992). Increasing evidence indicates a link between low blood cholesterol levels and a number of human diseases including tuberculosis (TB) (PerezGuzman et al, 2005; Deniz et al, 2007). It is reported that hypocholesterolemia promotes the development of TB whereas hypercholesterolemia confers some protection against infection with Mycobacterium tuberculosis (MTB) (Wilson et al, 2003; Perez-Guzman et al, 2005). Despite the existence of such links between cholesterol and TB, it is not known to which extent the treatment of the disease affects lipid indicators in patients with TB.
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