Abstract
Co-morbidity of hypertension and dyslipidemia are found to be high in type-2 diabetes mellitus (DM) patients particularly with poor glycemic control. This study was aimed to assess the prevalence of dyslipidemia and its correlations with anthropometric and blood pressure variables among type-2 DM patients. The study was conducted on 314 type-2 DM patients at Hawassa University Comprehensive Specialized Hospital from February 28 to May 30, 2017. Socio-demographic and other data was collected using interview-directed structured questionnaire. In addition, serum biochemical parameters determined after overnight fasting and dyslipidemia was defined based on United State National Cholesterol Education program-III criteria. Statistical analysis such as Chi-square, student’s t-test/ Mann-Whitney U test, and Pearson correlation coefficient were conducted using Statistical Package for Social Sciences (SPSS) Version 20. The result showed that two hundred eight six (91.1%) participants had a minimum of one lipid parameter abnormal, which is well suited for the diagnosis of dyslipidemia. The prevalence of low HDL-cholesterol, high LDL-cholesterol, triglycerides and TC (total cholesterol) were 60.8, 14.3, 70.4 and 32.8%, respectively. The mean values of TC, LDL-cholesterol and uric acid (UA) were significantly higher among patients with body max index (BMI) ≥25 kg/m2 when compared to those with BMI <25 kg/m2 (p<0.01 for all). In addition, TC and TG were significantly higher among patients with BP ≥130/85 mmHg when compared to those patients with BP <130/85 mmHg (p<0.001 for both parameters). Triglycerides was significantly correlated with BMI, UA and hypertension (r=0.326, 0.553 and 0.22), respectively. TC showed significant correlation with BMI, UA and fasting blood sugar (FBS) (r=0.326, 0.298 and 0.132), respectively. Moreover, LDL-cholesterol was significantly correlated with waist circumference, BMI and FBS (r=0.16, 0.189 and 0.173), respectively. In conclusion, dyslipidemia is significantly higher in diabetes patients and it correlated with BMI, WC, blood pressure and UA. Therefore, lipid profiles should be performed periodically through treatment follow-up and proper management of correlated factors is vital in order to limit risks of cardiovascular diseases. Key words: Anthropometric parameters, dyslipidemia, uric acid, hypertension, type-2 diabetes.
Highlights
Diabetes mellitus (DM) is a progressive noncommunicable chronic disease and insulin hormone absolute deficiency/resistance caused it
Median values of Systolic BP (SBP), diastolic BP (DBP) and TGs were significantly higher in overweight to obese patients when compared to those patients who have body max index (BMI)
Two hundred eighty six (91.1%) of the participants had a minimum of one lipid parameter abnormal that is compatible with the diagnosis of dyslipidemia according to National Cholesterol Education Program adult treatment panel (NCEP)-ATP III guideline
Summary
Diabetes mellitus (DM) is a progressive noncommunicable chronic disease and insulin hormone absolute deficiency/resistance caused it. Dyslipidemias may have a contribution to accelerated atherosclerosis and it is a risk factor for developing coronary artery disease (CAD) (American diabetic association, 2000). Comorbidity with hypertension (HTN) and dyslipidemia are found to be high in type-2 DM patients with poor glycemic control The relationship of these dysregulations proposes that these patients may be at a higher risk of developing cardiovascular diseases (CVDs) (Prabodh et al, 2012). These combined metabolic disorders like hypertension and hyperlipidemia may lead to cardio-cerebrovascular diseases and stroke, which may eventually lead to death (Sun et al, 2014). High concentration of free fatty acids prevents insulin mediated glucose uptake in the body and it predisposes to overproduction of very low-density lipoprotein cholesterol (VLDL-c (Mithal et al, 2014; Shradha and Sisodia, 2010)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
