Abstract
Burns are the most damaging kind of injuries, major global public health crisis and the fourth most common types of trauma. Decision making in the treatment of burns remains a challenge despite existence of improved assessment techniques and treatment procedures. One of the most complications in healing of burn tissues is necrosis. Several medicinal plants were used to treat skin disorders as burn wounds and necrosis so far. In our traditional medicine, one of the non-surgical methods for debridement of necrotic tissues is using toasted barley in sesame oil. Animal was used, because of the lack of previous scientific research about this herbal mixture for debridement of necrotic tissue. After being anesthetized, the second-degree burns were created in rats. Animals were divided into group I, not treated (control group) and group II treated with fibrinolysin ointment 3% (positive control group). Groups III, IV and V were treated with 1, 3 and 5% w/w doses of toasted barley in sesame oil, respectively. Histopathological and clinical findings showed that treated tissues, especially at dose of 5% w/w were more debrided. Therefore, with respect to our results, this herbal based compound can be used as remedy for debridement of necrotic tissue. Key words: Burn, debridement, necrosis, sesame oil, toasted barley.
Highlights
IntroductionBurns and damages to the skin due to heat, electricity or chemicals, associated with pulmonary damages, are the most important causes of morbidity, mortality and disability (Iqbal et al, 2013)
Skin is the most coated barrier of the body
Type and color, a lot of secretions were found in all groups except group II and V which were treated with fibrinolysin and 5% toasted barley in sesame oil, respectively (Table 1)
Summary
Burns and damages to the skin due to heat, electricity or chemicals, associated with pulmonary damages, are the most important causes of morbidity, mortality and disability (Iqbal et al, 2013). Because burns have several complications and patient is involved in the long term treatment of lesion, this damage is the worst kind of trauma (Lawrence et al, 2012; Carneiro, 2002). There are many researches on the epidemiology, etiology and consequences of burns. In children under 14 year of age, flame burns is the most common causes of burn injury with average rate of 19%, mortality rate of 6.4% and 6% outbreak (Maghsoudi et al, 2005) and children under the age of 12 are more at risk, making up 69.5% of all admissions (Scheven et al, 2012).
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