Abstract
This study was an extension of our previous antiemetic work. Many researchers quoted Cynodone dactylon as anti emetic agent but none of them have provided strong pharmacological evidence for it, which drove us for its therapeutic evaluation. Crude aqueous rhizome extract of C. dactylon was evaluated for anti-emetic activity. Emesis was induced by the oral administration of copper sulphate, fresh aqueous extract of Brasica compestris while intravenous Cisplatin was used to induce emesis in fifteen days age chicks of either sex. The anti-emetic activity was determined by calculating the mean decrease in number of emesis in comparison to those of control and standards. C. dactylon (50 and 100 mg/kg body weight orally) showed remarkable emesis suppressant activity when compared with standard drugs chlorpromazine, domperidone and metoclopramide. Both the doses showed remarkable antiemetic activity. Key words: Antiemetic, Cynodone dactylon, chick emesis model, domperidone, metoclopramide, chlorpromazine, Brasica compestris.
Highlights
Vomiting is a means by which gastrointestinal tract rids itself of its contents when upper gastro intestinal tract (GIT) excessively irritated, over distend or even over excited (Guyton and Hall, 2011)
Results of the antiemetic activity of aqueous extracts of C. dactylon at both concentrations are given in Figures 1 to 3
C. dactylon blocked the H1 receptors of gastric mucosa so that thiocynates of Brasica failed to stimulate H1 receptors and release of histamine by irritation which would in turn stimulate chemotrigger zone of medulla for emesis
Summary
Vomiting is a means by which gastrointestinal tract rids itself of its contents when upper gastro intestinal tract (GIT) excessively irritated, over distend or even over excited (Guyton and Hall, 2011). Chemorecepter trigger zone gets excited with artificial electrical stimulation and drugs (Morphine, digitalis derivatives and chemotherapeutic agents). Motion sickness and classical migraine quite often excite chemorecepter trigger zone for vomiting (Kumar and Clark, 2002). Irritable bowel syndrome and gestro-eosophygeal reflux disease (www.bnf.org), partial or complete bowel obstruction, uremia and brain metastases are contributing factors (www.pakcancer.com). Electrolyte imbalance such as hyponatrremia, hypercalicemia and hyperglycemia induces emesis (www.cancer.org)
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