Abstract
Helicobacter pylori is a microaerophilic spiral-shaped Gram-negative bacterium that infects approximately 50% of the world’s population, particularly in developing countries. Infections early in childhood are postulated to induce a low-grade chronic inflammatory condition. This study aimed to determine the prevalence of H. pylori virulence genotypes ureA, vacA, cagA and babA2 among asymptomatic Egyptian infants and to define the possible infection associated risk factors. Non invasive test using polymerase chain reaction on stool samples was used for detection of these genes. Prevalence of H. pylori among those infants was 88.9%. Prevalence of ureA, vacA, cagA and babA2 was 86.9, 98.8, 71.4 and 67.8%, respectively. Risk factors significantly associated with infection included bed sharing, premastication of food and nursery attendance (P<0.005). The prevalence of H. pylori infection among Egyptian infants is very high with high prevalence of virulence genotypes, so follow up of these infants and repetition of this study on a wider scale is recommended. Key words: Helicobacter pylori, virulence, Egypt, infants.
Highlights
Non-inv vasive e detec ction off Helic cobacte er pylo ori viru ulence gen notype es ureA
This study aimed to determine the prevalence of H. pylori virulence genotypes ureA, vacuolating cytotoxin A (vacA), cytotoxin associated gene A (cagA) and babA2 among asymptomatic Egyptian infants using stool samples as a non invasive screening test
Egyptian infants included in the study should fulfilled the following criteria (a) aged ≤24months (b) asymptomatic regarding gastrointestinal (GIT) symptoms (c) no antibiotics received within the 2 months before stool collections
Summary
Non-inv vasive e detec ction off Helic cobacte er pylo ori viru ulence gen notype es ureA. Helicobacte er pylori is a microaeroph m hilic spiral-sh haped Gram-n negative bac cterium that infects appro oximately nfections ea. 50% of the world’s pop pulation, parrticularly in developing countries. Thiis study aim med to determine the prevalence of H. pylori virulence v genotypes ureA. A2 among asy ymptomatic Egyptian infants and to define th he possible in nfection associated risk factors. Non n invasive te est using pollymerase chain reacttion on stooll samples wa as used for detection d of these genes s. Prevalence of ureA, vacA, cagA and babA2 was 86.9, 9. Risk facto ors significan ntly associate ed with infec ction include ed bed sharin ng, premastic cation of food and nu ursery attend dance
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