Abstract
Molecular markers; DNA, argyrophilic nucleolar organiser regions (AgNORs) and telomerase enzymes play important role in diagnosis of nephrotoxicity induced by potassium bromate (KBrO3). In the present study, the effects of Launaea procumbens against KBrO3 induced molecular changes in male rats are determined. 36 male albino rats (180 to 200 g) were divided into 6 groups. Group I was given saline (1 ml/kg body weight (b.w.), 0.85% NaCl) and DMSO (1 ml/kg b.w.); group II was treated with KBrO3 (20 mg/kg b.w., i.p.); group III, IV, V and VI were administered with KBrO3 and after 48 h with L. procumbens methanolic extract (200 mg/kg b.w. LPME), chloroform extract (200 mg/kg b.w. LPCE), ethyl acetate extract (200 mg/kg b.w. LPEE), and n-hexane extract (200 mg/kg b.w. LPHE), respectively. All the treatments were given twice a week for four weeks. The results revealed that KBrO3 induced oxidative stress as evidenced by the significant alteration in DNA, AgNORs and telomeres enzymes of kidney which was restored with various fractions of L. procumbens might be due the presence of bioactive compounds. Key words: Argyrophilic nucleolar organiser regions (AgNORs), Launaea procumbens, DNA, Telomerase enzymes.
Highlights
Phytotherapy means the use of bioactive compounds extracted from medicinal plants and their utilization as medicines or in the preparation of health-promoting drugs
The results revealed that KBrO3 induced oxidative stress as evidenced by the significant alteration in DNA, argyrophilic nucleolar organiser regions (AgNORs) and telomeres enzymes of kidney which was restored with various fractions of L. procumbens might be due the presence of bioactive compounds
Khan and Sultana (2005) reported that the induction of KBrO3 cause oxidative DNA damages in rats which support our investigations. These results show that the extract of both plants contain bioactive compounds which play important role in DNA repair
Summary
Phytotherapy means the use of bioactive compounds extracted from medicinal plants and their utilization as medicines or in the preparation of health-promoting drugs. Many medicinal plants and their isolated compounds have been used for chemotherapy in living cells (Gilani et al, 1992). Recent studies are involved in the identification and isolation of new therapeutic compounds of medicinal importance from higher plants for specific diseases (Khan et al, 2009; Khan et al, 2010a, b; Sahreen et al, 2010). (Asteraceae) is used as a food and washing agent (Wazir et al, 2007) against rheumatism and is used as galactogogues in increasing milk production (Parikh and Chanda, 2006). It possesses salicylic acid, vanillic acid, synergic acid, 2-methyl-resercinol, gallic acid and is used against plant pathogenic fungi, 158 Afr. J.
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