Abstract
The stem bark of Stryphnodendron adstringens, popularly known in Brazil as "barbatimão", has many biological activities, including antifungal activity. Considering the increasing interest of using "barbatimão" extract in the treatment of vaginal candidiasis, the aim of this study was to propose a pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as a pharmacological agent in vaginal gels, as well as to evaluate the validation parameters for the determination of phenolic compounds. UV/Vis spectrophotometry was used as a quantitative method for quality control of topical gel and a proanthocyanidin polymers-rich fraction was used in this work. The proposed gel seems suitable for use in vaginal infections, and the analytical method was linear, specific, precise, accurate, reproducible and robust. This methodology complies with analytical application demands and it is easily performed in work routine. Key words: Barbatimão, polyphenols, Stryphnodendron adstringens, UV/Vis spectrophotometry, vaginal gel, validation method.  
Highlights
The genus Stryphnodendron belongs to the Leguminosae family, which has about 48 species, all rich in tannin and native to the savannah in tropical and subtropical climates
Phytochemical studies performed with S. adstringens showed that it is composed of proanthocyanidin polymers, mainly several flavan-3-ols derivatives, such as prodelphinidins and prorobinetinidins (Lopes et al, 2008; Mello et al, 1999, 1996)
Considering the increasing interest in vaginal candidiasis treatment, we propose a pharmaceutical topical gel for vaginal use containing a proanthocyanidin polymers-rich fraction from S. adstringens (F2)
Summary
The genus Stryphnodendron belongs to the Leguminosae family, which has about 48 species, all rich in tannin and native to the savannah in tropical and subtropical climates. Among them is Stryphnodendron adstringens (Mart.) Coville. The content of tannins in the bark of S. adstringens reaches a minimum of 8% according to the Brazilian Pharmacopeia (Albuquerque et al, 2007; ANVISA, 2010). The stem bark of S. adstringens, popularly known in Brazil as "barbatimão", is employed in popular culture as an anti-inflammatory, antibacterial and antiulcer treatment (Agra et al, 2008; Albuquerque et al, 2007). Phytochemical studies performed with S. adstringens showed that it is composed of proanthocyanidin polymers, mainly several flavan-3-ols derivatives, such as prodelphinidins and prorobinetinidins (Lopes et al, 2008; Mello et al, 1999, 1996)
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