Abstract
Previous investigations indicated that glucagon-like peptide-1 (GLP-1) played important roles in bone turnover via GLP-1 receptors (GLP1Rs) in postmenopausal state. Furthermore, polymorphisms in GLP1R gene were suggested to affect the function of GLP1Rs and be associated with many diseases. However, the relationships between GLP1R polymorphisms and osteoporosis susceptibility and bone strength remain unexplored. To address this issue, a total of 458 Chinese Han postmenopausal women were included in this study. The bone mineral density (BMD) in the lumbar spine (L 2 -L 4) and femoral neck was measured by dual-energy X-ray absorptiometry (DEXA). A missense mutation (rs1042044) in GLP1R was genotyped using allele specific TaqMan probes. Our data showed that genetic variants of rs1042044 were significantly associated with osteoporosis (P = 0.003) and that the C allele of rs1042044 was a protective factor against osteoporosis compared to the A allele with gene dosage-dependent manner (OR, 0.579; 95% CI, 0.366 to 0.916 for AC genotype and OR, 0.404; 95% CI, 0.238 to 0.688 for CC genotype). These findings indicate that polymorphisms in GLP1R gene may affect BMD and development of osteoporosis in Chinese Han postmenopausal women, which provide novel insight into the mechanisms of osteoporosis development and target for personal prevention and treatment of osteoporosis. Key words : Glucagon-like peptide-1 receptor, single nucleotide polymorphism, osteoporosis, bone mineral density.
Highlights
Osteoporosis is a prevalent metabolic bone disease and an important and complex health problem in postmenopausal women (Riggs and Melton, 1986; NIH, 2001)
Was affected by a series of bone mass modulating factors, such as vitamin D receptor, estrogen receptor, and osteoprotegerin etc., and that polymorphisms in genes encoding these factors were significantly associated with osteoporosis risk (Horst-Sikorska et al, 2013; Gennari et al, 2005; Arko et al, 2005; Wang et al, 2013)
A case-control study was performed with a total of 458 Chinese Han postmenopausal women, including 223 randomly selected primary postmenopausal osteoporosis patients, who were enrolled from Kunming General Hospital of Chengdu Military
Summary
Osteoporosis is a prevalent metabolic bone disease and an important and complex health problem in postmenopausal women (Riggs and Melton, 1986; NIH, 2001). This kind of skeletal disease is characterized by low bone mineral density (BMD) and deterioration of bone tissue, and generally believed to be a multifactorial. GLP-1 analogue, exendin-4, enhances bone strength and prevents the deterioration of trabecular microarchitecture (Ma et al, 2013) These findings suggest that GLP1R is an important bone mass modulating factor. In order to prove this hypothesis, in the present study, we investigated the relationship between a common tag-SNP (rs1042044) of GLP1R and BMD in Chinese Han postmenopausal women
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
