Abstract
The use of natural products for skin treatments has been increased. Mainly, those of topical action incorporated to pharmaceutical forms, since they allow the restoring of skin integrity after possible attacks. In this context, the plant Platonia insignis Mart has been widely used for the treatment of various skin diseases and as wound healing medicine in folk medicine. The aim of this study is to evaluate the wound healing activity of a cream formulated containing triglyceride isolated from P. insignis Mart called 1,3-distearoyl-2-oleoylglycerol (TG1) in skin lesions induced in Wistar rats by macroscopic and histological analysis of the wounds. The animals were randomly divided into 5 groups according to the treatment to be performed. The negative control received saline solution, the positive control received collagenase and the other groups received cream containing the triglyceride at concentrations of 5, 10 and 15%. The results showed effectiveness in the healing of wounds through reduction of their diameter compared to negative control. Histological analysis demonstrated the inflammatory and proliferative phenomena of healing in wounds of rats. The cream with TG1 in three concentrations demonstrated efficacy in wound healing, as evidenced by macroscopic and microscopic analyses of lesions in Wistar rats. Based on this, a further development of phytomedicines for wound care is suggested. Key words: Cutaneous wounds, healing, Platonia insignis.
Highlights
Natural products from plants, animals and microorganisms are a huge source of different chemicals that can be used by pharmaceutical industries for production of medicines (Ogbourne and Parsons, 2014; Fonseca et al, 2014)
The assessment of the characteristics that the active ingredient incorporated into the base in semisolid pharmaceutical has fundamental importance in the process of wound healing in rats
Mice and rats are routinely used as an experimental tool to study novel bioactive medicines and healing remedies (Surey et al, 2014; Fernandes et al, 2014; Sá et al, 2012; Magalhães et al, 2010)
Summary
Natural products from plants, animals and microorganisms are a huge source of different chemicals that can be used by pharmaceutical industries for production of medicines (Ogbourne and Parsons, 2014; Fonseca et al, 2014). Bioactive substances, such as alkaloids, steroids, glycosides, saponins, tannins and flavonoids present mainly in plants, are potential therapeutic agents that can help in wound healing (Adiele et al, 2014; Kuntal, 2013). This species, popularly known as “bacurizeiro”, is a monotype vegetal belonging to the Clusiaceae family
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