Abstract
Ilex paraguariensis (mate-tea) has been used to treat type-2 diabetes and emphysema. This tea presents antioxidant activity and promotes satiety, body weight lowering and improves bone mineral density. Blood constituents have been labeled with technetium-99m (99mTc) and this labeling depends on the presence of a reducing agent. Stannous chloride has been widely utilized with this purpose. The influence of natural and synthetic drugs in this procedure has been reported. It was evaluated with effect of an aqueous mate-tea extract on the labeling of blood constituents with 99mTc and on the morphology of erythrocyte. Blood samples of Wistar rats were incubated with mate-tea extract, stannous chloride and 99mTc-sodium pertechnetate. Blood cells (BC) and plasma (P) were isolated. BC and P were also precipitated and soluble (SF) and insoluble (IF) fractions separated. The radioactivity was counted and percentage of incorporated radioactivity (%ATI) determined. Blood smears were performed for morphological evaluation. The data show a significant (p < 0.05) alteration of %ATI in BC, IF-C and IF-P as well as on the erythrocyte morphology. These findings could be related to the redox properties of the substances of the mate-tea extract, as well as due to the interference in the transport of stannous and/pertechnetate into the BC due to the morphological alterations of the erythrocytes. Key words: Ilex paraguariensis, blood constituents, radiolabeling, morphology, technetium-99m, stannous ion.
Highlights
IntroductionIlex paraguariensis (mate-tea) is an herb whose leaves are utilized to prepare infusion
Ilex paraguariensis is an herb whose leaves are utilized to prepare infusion
The results show an inhibition in the process of labeling of the cells where the efficiency of labeling was reduced significantly (p < 0.05) for all the concentrations of the mate-tea extract tested
Summary
Ilex paraguariensis (mate-tea) is an herb whose leaves are utilized to prepare infusion. This infusion is a popular drink known as mate-tea. It has been consumed under different forms. Various properties of this plant in the. Braga et al 2687 form of tea have been already described and it has been popularly used to treat type-2 diabetes (Hussein et al, 2011) and emphysema (Lanzetti et al, 2011). Data have demonstrated that this tea possesses antioxidant activity (Coentão et al, 2011) and promotes satiety, body weight lowering (Hussein et al, 2011) and improves bone mineral density (Confort et al, 2012). Consumption of mate powder would significantly contribute to antioxidant and stimulant intake, providing high amounts of phenolic acids, tannins and methylxanthines with biological effects potentially beneficial for human health (Vieira et al, 2010)
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