Abstract
A new series of nine (3a-c, 4a-f) novel compounds was synthesized in high yields by condensing 5-substituted isatin with 3amino-2-phenyl-quinazoline. The chemical structures of the new compounds were confirmed by modern analytical techniques. These compounds were investigated for in vitro antibacterial, antifungal and anti-mycobacterial activities using in vitro model. Antibacterial activity was evaluated on gram positive as well as on gram negative bacteria using cup plate and liquid dilution methods. Among the series of these nine compounds, compound 3a, 3c, 4a, 4d, 4e were effective against gram positive and gram negative bacteria, while as compounds 3c, 4c, 4d, 4e, 4f exhibited potent antifungal activity. Moreover compound 4e was highly active against M. tuberculosis H37 Rv with 75% inhibition in comparison with standard drugs isoniazid and gentamycin. It is conceivable that further derivatization of these compounds could result potent antimicrobial agents.
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