Abstract
In this study, the wound healing activity of total aqueous extract and the mucilage of leaves of plant Cocculus hirsutus (L) Diels was evaluated on excision wound model. Dermal films were prepared using total aqueous extract, mucilage and polyvinyl alcohol as a polymer base. The prepared polysaccharide solutions of the total extract and the isolated mucilage were evaluated for its physiochemical properties and total bacterial count. The prepared dermal patches were subjected biodegradation studies. The results indicate statistically significant wound healing response of the dermal patch containing the aqueous extract and the mucilage of leaves of plant C. hirsutus when compared with control group and groups subjected to standard marketed medicated dermal patch. The cost effective factor and biodegradation of the prepared dermal wound healing patch was also found to be significant. Key words: Cocculus hirsutus (L.) Diels, wound healing, excision wound model, Dermal patches.
Highlights
Wound is a breach formed in the normal continuvum of the cellular and molecular structure of the body thereby creating a disruption in the cellular, anatomic and as well as in their functional continuity
The results indicate statistically significant wound healing response of the dermal patch containing the aqueous extract and the mucilage of leaves of plant C. hirsutus when compared with control group and groups subjected to standard marketed medicated dermal patch
Total aqueous extract was prepared by maceration process and mucilage rich in polysaccharide was isolated from the leaves of C. hirsutus
Summary
Wound is a breach formed in the normal continuvum of the cellular and molecular structure of the body thereby creating a disruption in the cellular, anatomic and as well as in their functional continuity. Wound healing or wound repair is an intricate process in which the skin or organ or tissue repairs itself after injury It comprises of a continuous sequence of inflammation and repair in which epithelial endothelial inflammatory cells, platelets and fibroblasts briefly come together outside their normal domains, interact to restore a semblance of their usual discipline and having done to resume their normal function (Clark, 1993; Singer and Clark, 1999; Sahl and Clever, 1994). The patch used for the wound healing includes an ultra-concentrated formula infused into a small discreet dermal patch which sticks to the body. This uses advanced physiological technology to introduce the formula into the user’s bloodstream in a controlled, timely manner further showing the wound healing phases. More attention is paid to pollution caused by non biodegradable synthetic polymers which has resulted in worldwide concern on biodegradable substances such as polysaccharide, lipid, protein and other composite films (Karlsson and Albertsson, 1998)
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