Abstract
Vascular cognitive impairment refers to the risk factors derived from blood vessels caused by a variety of levels and types of cognitive impairment, such as vascular mild cognitive impairment, vascular dementia and mixed dementia. Using acupuncture for mild cognitive impairment leukoaraiosis has impacts on the functional magnetic resonance. To know the neurotransmitter changes before and after acupuncture intervention in mild cognitive impairment with the functional magnetic resonance brain, laboratory for music and communication in infancy (LAMCI) cases (23), and 13 normal subjects (control group) cases were observed. Acupuncture treatment and the natural process group were observed for 3 months, respectively. Neuropsychological evaluation and magnetic resonance spectroscopy check were executed at the beginning and end of each day. Neuropsychological assessment includes mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA), magnetic resonance imaging (MRI), spectroscopy N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, and myoinositol (MI)/Cr. The results showed that acupuncture can be used as an effective means of intervention for mild cognitive impairment leukoaraiosis, which can reduce activated brain regions in order to raise the efficiency of the task when stimulation is processed. Key words: Acupuncture, leukoaraiosis, mild cognitive impairment, functional magnetic resonance, magnetic resonance spectroscopy.
Highlights
Vascular cognitive impairment refers to various types and degrees of cognitive impairment caused by risky factors of vessels, which include mild cognitive impairment, vascular dementia and mixed dementia
The results showed that acupuncture can be used as an effective means of intervention for mild cognitive impairment leukoaraiosis, which can reduce activated brain regions in order to raise the efficiency of the task when stimulation is processed
minimental state examination (MMSE) score and NAA/Cr Cho/Cr and MI/Cr showed no correlation (P > 0.05); score of montreal cognitive assessment (MoCA) had no correlation between NAA/Cr and MI/Cr and Cho/Cr (P < 0.05) (Table 4)
Summary
Vascular cognitive impairment refers to various types and degrees of cognitive impairment caused by risky factors of vessels, which include mild cognitive impairment, vascular dementia and mixed dementia. The essay reveals the study of mild cognitive impairment leukoaraiosis by means of functional MRI, with reference to practical clinical state and long time of acupuncture intervention, so as to find the clinical changes of these patients with the help of neuropsychological assessment. Exclusion criteria (1) Diagnosis of dementia; (2) Cerebral hemorrhage, cerebral infarction, lacunar infarction, subarachnoid hemorrhage, Binswanger's disease, multiple sclerosis, encephalitis, brain trauma, early aged glial atrophy, mental illness, hypoxemia, carbon monoxide (CO) poisoning, and cognitive impairment caused by low blood sugar; (3) Depression (HAMD) score ≥ 17 points; (4) Obvious focal neurological symptoms and signs, or other somatic diseases that seriously influence the psychological tests; (5) Outside the age range; (6) With severe original disease in liver, kidney, hematopoietic system, and the endocrine system; (7) With in 1 month taking drugs that may influence the cognitive ability (8) Not the type of kidney inefficiency, kidney phlegm and blood stasis syndrome in TCM (9) Subjects who cannot follow the research procedures. Exclusion standard (1) Subjects below the criteria were selected by mistakes (2) Standard subjects did not receive acupuncture (3) Poor compliance of the subjects (4) Subjects with serious accidents, complications or special biological changes (5) Retreat by themselves
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