Abstract
This study aimed to evaluate the effect of supplementation of sucralose and fructose on the metabolism of adolescent rats. Eighteen male Wistar rats were divided into 3 groups: control group (GC), fructose group (GF) treated with 50 mg/kg of fructose, and sucralose group (GS) receiving 50 mg/kg of sucralose for 24 days. The weight and feed intake were measured weekly. At the end of the experiment, some biochemical parameters, histopathology of the liver and biodistribution of the radiotracer 99mTc-sodium phytate in liver and blood were analyzed. The GF showed higher body weight only in the first week compared with GS and GC (p<0.05). Histopathology and % ATI/g radiotracer 99mTc-sodium phytate in liver and blood were not different between the groups. The GF showed higher values ​​of aspartate aminotransferase activity, bilirubin, alkaline phosphatase activity and gamma glutamyl transferase activity, compared with the other groups (GC and GS) (p<0.05). Activity of alanine aminotransferase and albumin level of GF were higher than GS (p<0.05). For other parameters, no statistical difference was observed. It was concluded that the use of fructose during the experiment was able to alter hepatic enzymes, but on the other hands, the use of sucralose caused no change. Key words: Sucralose, fructose, adolescent rats, radiopharmaceutical.
Highlights
Excessive consumption of carbohydrates is responsible for metabolic abnormalities in individuals, leading to morbidities such as diabetes mellitus (DM), obesity, and consequent increase in population mortality
There was no significant difference in the initial body weight of the animals distributed in three groups: GC (125.86 ± 5.18); GF (128.00 ± 7.04); GS (122.86 ± 11.36)
There was no significant difference in the biodistribution of radioactivity in the studied organs
Summary
Excessive consumption of carbohydrates is responsible for metabolic abnormalities in individuals, leading to morbidities such as diabetes mellitus (DM), obesity, and consequent increase in population mortality. Sucralose has qualities that are interesting for the consumers and to the food and beverage industry. Some of these qualities are: it is very stable at high temperatures and low pH; it does not leave an aftertaste like many others sweeteners do; it cannot be hydrolyzed during the digestion and metabolic processes since the carbon-chloro linkage is very stable; it is fairly soluble in water and it presents high stability both in crystalline and solution forms (Grotz and Munro, 2009; Rodero et al, 2009). Fructose is found naturally in fruits and honey, but may be obtained through industrial process for the inversion of sucrose. Fructose is widely consumed by diabetics, because it does not require insulin to enter the cell (Barreiros et al, 2005)
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