Abstract
This study was made to investigate in-vitro membrane stabilizing, thrombolytic, antioxidant and antimicrobial activities of ethanolic leaf extract of Coccinia indica. Different extractives showed significant membrane stabilizing activity. The ethanol soluble fraction showed (45.36±0.45 % and 64.05±0.22 %) of Red blood cells haemolysis inhibition under heat and hypotonic solution induced conditions, respectively. Mention worthy that carbon tetrachloride soluble fraction of C. indica exhibited highest thrombolytic activity 57.94±0.23% in a comparison with standard streptokinase (SK) (68.89±0.35 %). The antioxidant activities were determined by 1,1â€diphenylâ€2â€picrylhydrazyl (DPPH) free radical scavenging. In this case, ethanol soluble fraction (ESF) of crude extract showed fairly significant scavenging (with IC50 value of 2.52 μg/ml) as opposed to a well-known antioxidant, butylated hydroxytoluene (BHT) (IC50 value of 3.99 μg/ml). Pet ether soluble fraction (PESF) and ESF showed mild inhibitory effects against some Gram-positive and Gram-negative bacteria (zone of inhibition was 12 and 13 mm). The overall findings of the studies demonstrated that the leaves of C. indica has fairly significant membrane stabilizing and thrombolytic activity, mild to moderate antioxidant and antimicrobial potential. Thus, may indicated the scientific basis of C. indica leaves as a remedy for traditional uses against fever, pain, oxidative stress, inflammation, infectious diseases, diabetes, etc. Key words: Coccinia indica, in vitro, thrombolytic, 1,1â€diphenylâ€2â€picrylhydrazyl, antimicrobial activities.  
Highlights
The antioxidant activities were determined by 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free radical scavenging
The overall findings of the studies demonstrated that the leaves of C. indica has fairly significant membrane stabilizing and thrombolytic activity, mild to moderate antioxidant and antimicrobial potential
Coccinia indica is botanically known as Ivy Gourd (Family: Cucurbitaceae) and traditionally familiar as “Telakucha”
Summary
Coccinia indica is botanically known as Ivy Gourd (Family: Cucurbitaceae) and traditionally familiar as “Telakucha”. This opportunistic plant is used as wild vegetable in several areas of Asia specially in cooking and as medicines (Sadique et al, 1989). It assumed to have various significant medicinal properties like analgesic, antipyretic, anti-inflammatory, antimicrobial, antiulcer, antidiabetic, antioxidant, hypoglycemic, hepatoprotective, antimalarial, antidyslipidemic, anticancer, antitussive and mutagenic properties, etc. (Rahmatullah et al, 2009; Priyanka et al, 2016). It is an annual creeper having tuberous roots, grown over ground.
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