Abstract
Herbs have been a great source of natural substances used to prevent many cardiovascular diseases (CVD). Blood lipid levels and coagulation parameters are probably the major determinant for producing CVDs. The present study was undertaken to evaluate the hypo-lipidemic and anti-thrombotic activities of aqueous extract of Myrtus communis L. fruit (AEM) in cholesterol-fed rabbits. Hyper-lipidemia was induced following administration of cholesterol for 45 days. Animals of treated group were administered AEM daily for 30 and 45 days at dose of 50 mg/kg. Biochemical tests were performed at the end of dosing that is, on 31st day and again on 46th day. The administration of AEM (50 mg/kg/day) revealed reduction in serum triglycerides and low density lipoprotein; there was also an increase in thrombin and fibrinogen time. Results of present study indicate that the extract exhibited hypolipidemic effects and has also an effect on blood coagulation parameters which may be of value in CVDs. However, further studies are necessary to explore the precise mechanism of action of these effects. Key words: Herbs, lipid profile, blood coagulation, rabbits.
Highlights
Traditional medicine based on herbal remedies has always played a vital role in the health care systems of many countries (Verma et al, 2007) owing to their lesser side effects than synthetic drugs (Srivastava et al, 2006).There are many plants which have been listed in the traditional systems of medicine, and the individuals suffering from cardiovascular diseases (CVD), hyperlipidemia and ischemic heart disease, get relief from these medicines (Mahmood et al, 2010)
There are many plants which have been listed in the traditional systems of medicine, and the individuals suffering from cardiovascular diseases (CVD), hyperlipidemia and ischemic heart disease, get relief from these medicines (Mahmood et al, 2010)
aqueous extract M. communis (AEM) have been found to reduce low density lipoprotein cholesterol (LDL-C) and increase fibrinogen time that is, decrease fibrinogen level which seems to be of clinical importance since there are studies which shows that increased fibrinogen has been associated with cardiovascular risks
Summary
Traditional medicine based on herbal remedies has always played a vital role in the health care systems of many countries (Verma et al, 2007) owing to their lesser side effects than synthetic drugs (Srivastava et al, 2006). There are many plants which have been listed in the traditional systems of medicine, and the individuals suffering from cardiovascular diseases (CVD), hyperlipidemia and ischemic heart disease, get relief from these medicines (Mahmood et al, 2010). 80% of the world’s population are using herbal drugs for their primary health care (Azaizeh et al, 2003; Mahmood et al, 2010). (Myrtaceae) is widely distributed all over the Mediterranean region and the Middle East It is an evergreen shrub, about 1 to 5 m high, h as small. On lipid profile and blood coagulation in hyperlipidemia induced rabbits
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