Abstract
The effects of graded doses of medetomidine (100, 150, 200 and 250 µg/kg) on hematology as well as physiological and sedative indices were evaluated in this study using domestic pigeons. Sedation ranging from sternal to lateral recumbency, as well as adequate muscle relaxation was observed. The longest sedative effect was observed using the highest dose which was statistically significant (P < 0.05) from the other doses used. The differences in sedative scores between the groups was significant (P < 0.05) when the doses were compared. Significant decrease (P < 0.05) from the baseline values was observed on the physiological parameters, likewise when the physiological parameters between the graded doses were compared. The packed cell volume (PCV) and red blood cell count (RBC) values show significant increase (P < 0.05) with increase dose, but the white blood cells (WBC) does not show significant changes. This make medetomidine to be a potent sedative agent that can be used successfully for routine surgical and clinical procedures and the doses has to be carefully selected to avoid some of the unwanted effects on the physiological as well as hematological values in pigeons.
Highlights
Alpha-2-adrenoreceptor agonists are mostly used in combination with opioids, dissociative anesthetics, or as pre-anesthetic sedatives that reduce the amount of anesthetic agent to be used
Packed cell volume (PCV), hemoglobin concentration (Hb) and protein values are among the most important parameters in the assessment of health and diseases in birds and other mammals and packed cell volume (PCV) serves as a marker for hemogram in determining the number of
Results in this study reveals that increasing the dose of medetomidine has no effect on the induction time (Table 1)
Summary
Alpha-2-adrenoreceptor agonists are mostly used in combination with opioids, dissociative anesthetics, or as pre-anesthetic sedatives that reduce the amount of anesthetic agent to be used. Studies and clinical applications of medetomidine in pigeons examine its application as an inductive agent or a free anesthetic agent in combination with other drugs like ketamine and midazolam (Pollock et al, 2001; Lumeij and Deenik 2003; Uzun et al, 2003). Erythrocytes and circulating Hb (Hawkey et al, 1983, 1984; Benjamin, 1985) These factors necessitate the assessment of blood parameters and changes that may result when sedatives and other related drugs were used in birds and other animals. This study was designed to examine the effects of graded doses of medetomine as a possible sole agent for immobilization of pigeons in clinical procedures
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